辽宁石油化工大学学报2023，Vol.43Issue(6)：11-16,6.DOI:10.12422/j.issn.1672-6952.2023.06.002
钌(Ⅱ)催化1-苯基-5-吡唑啉酮和碳酸亚乙烯酯的偶联反应
Ruthenium(Ⅱ)-Catalyzed Coupling Reaction of 1-Phenyl-2-Pyrazolin-5-One with Ethylene Carbonate
摘要
Abstract
A novel ruthenium(Ⅱ)-catalyzed C-H/C-N annulation of 1-phenyl-2-pyrazolin-5-one with ethylene carbonate was designed.In this transformation,the vinylene carbonate acts as an ethynol or alkyne surrogate without any external oxidant as well as bases involved.The reaction exhibits a broad substrate scope with excellent functional group compatibility,affording a series of 1H-pyrazolo[1,2-a]cinnolin-1-ones in 42%～87%yields.A possible mechanism involving a sequential C-H activation/intramolecular C-N bond formation/CO2 or CO2-3 elimination is proposed.In addition,the reaction can also be carried out on a gram scale with satisfactory yield.关键词
钌(Ⅱ)催化/1-苯基-5-吡唑啉酮/碳酸亚乙烯酯/C-H活化/1H-吡唑并[1,2-a]噌啉酮Key words
Ruthenium(Ⅱ)catalysis/1-Phenyl-2-pyrazolin-5-one/Ethylene carbonate/C-H bond activation/1H-Pyrazolo[1,2-a]cinnolin-1-one分类
化学化工引用本文复制引用
王华,王欣,王贺,周明东,李蕾..钌(Ⅱ)催化1-苯基-5-吡唑啉酮和碳酸亚乙烯酯的偶联反应[J].辽宁石油化工大学学报,2023,43(6):11-16,6.基金项目
国家自然科学基金项目(21702087) （21702087）
辽宁省教育厅项目(L2020033). （L2020033）
