分析测试学报2023，Vol.42Issue(12)：1607-1614,8.DOI:10.19969/j.fxcsxb.23091802
气相色谱-串联质谱法测定化妆品中7种二甲基环硅氧烷
Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry
李思源 1陈安丽 1赵思雯 1严小红 1丁怡1
作者信息
- 1. 广州市药品检验所,广东 广州 510160
- 折叠
摘要
Abstract
A gas chromatography-tandem mass spectrometric(GC-MS/MS)method was developed for the simultaneous determination of 7 dimethylcyclosiloxanes in cosmetics.Cosmetics samples with different matrices were dispersed with isopropyl alcohol and extracted with n-hexane,then separated on a HP-5MS UI capillary column(30 m×0.25 mm×0.25 μm),and detected by GC-MS/MS in mul-tiple reactive ion monitoring(MRM)mode.The data were processed and quantified using the matrix-matched external standard method.The results showed that the 7 dimethylcyclosiloxanes had good linear relationships in the range of 50-1 000 ng/mL,with correlation coefficients(R)of 0.996 5-0.999 9.The limits of detection(LODs)and the limits of quantitation(LOQs)were in the range of 4.0-6.1 mg/kg and 13.2-20.4 mg/kg,respectively.The average recoveries were in the range of 85.1%-115%,with relative standard deviations(RSDs)of 0.90%-7.0%.The method was applied to test 102 batches of cosmetics sold on the market,and the detected components covered D4-D9.The method is convenient,fast,sensitive and accurate,which is suitable for the determination of the 7 dimethylcyclosiloxanes in cosmetics and could provide technical support for ensuring the quality and safety of cosmetics.关键词
气相色谱-串联质谱(GC-MS/MS)/二甲基环硅氧烷/化妆品Key words
gas chromatography-tandem mass spectrometry(GC-MS/MS)/dimethylcyclosiloxanes(DMCs)/cosmetics分类
化学化工引用本文复制引用
李思源,陈安丽,赵思雯,严小红,丁怡..气相色谱-串联质谱法测定化妆品中7种二甲基环硅氧烷[J].分析测试学报,2023,42(12):1607-1614,8.
