分子影像学杂志2023，Vol.46Issue(6)：957-963,7.DOI:10.12122/j.issn.1674-4500.2023.06.01
99mTc-MIBI SPECT/CT结合CT影像学特征在原发性甲状旁腺疾病中的价值
Value of 99mTc-MIBI SPECT/CT combined with CT imaging features in the diagnosis of primary parathyroid diseases
摘要
Abstract
Objective To investigate the clinical value of SPECT/CT and CT imaging features in primary hyperparathyroidism(PHPT)with inaccurate imaging location.Methods A total of 90 patients with PHPT confirmed by surgery and pathology were selected and divided into a missed diagnosis group(n=12)and a correct diagnosis group(n=78)according to pathological results,and a parathyroid lesion group(n=81)and a thyroid lesion group(n=29)according to pathological results.The same size areas of interest were delineated in the focal areas of parathyroid,thyroid and contralateral normal areas of parathyroid lesions on the SPECT/CT fusion images,and the radioactive counts of these different sites were recorded,and target-to-non-target ratio(T/NT)and target-to-non-target ratio(TBR)were calculated.The mean values of maximum CT density(CTmax),minimum CT density(CTmin)and mean CT density(CTavg)were collected at three consecutive layers.The data of each group were compared between groups,the working curve of subjects was drawn,and the diagnostic efficacy of each data was evaluated.Results On 99mTc-MIBI SPECT/CT images,the T/NT,TBR,volume,and diameter of the lesions in the missed group were smaller than those in the correctly diagnosed group,and the difference in T/NT between the two groups was statistically significant(P=0.002)and the diagnostic efficiency was the best,while there was no significant difference in TBR,volume,and diameter between the two groups(P>0.05).There was no significant difference in blood Ca and blood P between the parathyroid lesion group and the thyroid lesion group(P>0.05).The parathyroid hormone,TBR,CTmax,CTmin and CTavg in the thyroid lesion group were all lower than those in the parathyroid lesion group(P<0.05).The diagnostic efficiency of CTmax was the best,with AUC of 0.623,sensitivity of 74.10%and specificity of 62.50%.Conclusion SPECT/CT has better diagnostic efficacy than TBR in preoperative localization of PHPT,which can provide more valuable reference for preoperative localization of PHPT.It has good clinical value to treat TBR and CTmax with thyroid lesions.关键词
原发性甲状旁腺亢进症/SPECT/CT/甲状腺疾病Key words
primary hyperparathyroidism/SPECT/CT/thyroid disease引用本文复制引用
赵宇嘉,白侠..99mTc-MIBI SPECT/CT结合CT影像学特征在原发性甲状旁腺疾病中的价值[J].分子影像学杂志,2023,46(6):957-963,7.基金项目
内蒙古自治区科技计划项目(2021GG0236) （2021GG0236）
内蒙古自治区高等学校自然科学重点项目(NJZZ21039) （NJZZ21039）
青年科技人才发展项目(NJYT23074) （NJYT23074）
内蒙古自治区"草原英才"工程创新创业人才项目 （）
