分子影像学杂志2023，Vol.46Issue(6)：964-969,6.DOI:10.12122/j.issn.1674-4500.2023.06.02
18F-FDG联合11C-CFT PET显像分析帕金森病的价值
Value of 18F-FDG combined with 11C-CFT PET imaging in analyzing Parkinson's disease
摘要
Abstract
Objective To study the application of 18F-FDG and 11C-CFT PET imaging in the combined diagnosis,evaluation,and differential diagnosis of Parkinson's disease(PD).Methods A total of 107 patients admitted to our hospital from September 2018 to March 2022 who were initially diagnosed as PD according to clinical symptoms and the effectiveness of oral metoba were selected,and 43 healthy subjects were selected as the control group.Both groups underwent 18F-FDG and 11C-CFT PET imaging.11C-CFT analysis:The PD group was divided into two levels:H&Y 1-2(early)and H&Y 3-5(late).The 11C-CFT standard uptake values of the caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus were measured in the PD group and the control group.Independent sample t-test was used to compare the PD group and the control group.The caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus were then divided into three groups,Using one-way ANOVA for inter group comparison;18F-FDG analysis:Analyze the metabolic changes in the putamen,thalamus,caudate nucleus,and frontal parietal temporal occipital lobe based on the patient's motor symptoms.Results 11C-CFT PET imaging:At the early stage of H&Y 1-2,the contralateral posterior putamen of the affected limb showed low metabolism(P<0.05).Compared with the control group,some patients showed low metabolism in the contralateral anterior putamen and ipsilateral posterior putamen of the affected limb,and the results were statistically significant(P<0.05),while the ipsilateral anterior putamen and caudate nuclei of the affected limb were basically normal.In H&Y 3-5(late stage),the metabolism of the posterior putamen on the opposite side of the affected limb was lower(P<0.05).The opposite and ipsilateral posterior putamen and anterior putamen of the affected limb exhibited uneven hypometabolism,and the results were statistically significant(P<0.05);Comparing the caudate nucleus,anterior putamen nucleus,and posterior putamen nucleus,there were differences between the contralateral and ipsilateral groups of the affected limb in the early and late stages(P<0.05),providing additional evidence that the lesion originated in the posterior putamen nucleus;18F-FDG PET imaging:107 Parkinson's patients showed 81.31%increase in putamen metabolism,54.20%increase in thalamus metabolism,and 26.17%increase in caudate nucleus metabolism.The metabolic reduced area of the cerebral cortex showed 89.72%decrease in parietal lobe metabolism,57.94%decrease in frontal lobe metabolism,68.22%decrease in temporal lobe metabolism,and 14.02%decrease in occipital lobe metabolism.Conclusion 18F-FDG combined with 11C-CFT PET binuclear imaging provide objective data for clinical diagnosis,differential diagnosis,and evaluation of PD.关键词
帕金森病/18F-FDG/11C-CFT/正电子发射计算机断层/诊断Key words
Parkinson's disease/18F-fluorodeoxyglucose/dopamine transporter 11C-CFT/positron emission tomography/diagnosis引用本文复制引用
那孜木古丽·木塔尔别克,张奇洲,秦永德,李毓斌,张磊..18F-FDG联合11C-CFT PET显像分析帕金森病的价值[J].分子影像学杂志,2023,46(6):964-969,6.基金项目
新疆维吾尔自治区科技计划项目(201417101) （201417101）
