摘要
Abstract
Objective To compare the value of 68Ga-FAPI PET/CT and 18F-FDG PET/CT in the diagnosis and staging of head and neck tumors.Methods Fourty-five patients with head and neck tumors who underwent 68Ga-FAPI and 18F-FDG PET/CT dual imaging in our department were collected from October 2020 to June 2022.All patients were initially staged with two imaging methods.The differences in detection rates of primary lesions and metastatic lesions between 18F-FDG PET/CT and 68Ga-FAPI PET/CT were compared.The differences in maximum standard uptake value(SUVmax)and target to background ratio(TBR)values between the two examination methods were compared.Results The detection rates of primary tumor,lymph node metastasis and distant metastasis by 68Ga-FAPI and 18F-FDG PET/CT were 97.78%and 97.78%,90.48%and 96.54%,75%and 87.5%,respectively.The FAPI-SUVmax and FDG-SUVmax of primary tumors were 10.90 and 10.45,respectively,and the difference was not statistically significant(P=0.551).The FAPI-TBR and FDG-TBR were 11.50 and 9.80,respectively,and the difference between two imaging in TBR was statistically significant(P=0.007).68Ga-FAPI PET/CT upstaged 6 cases of T staging,but underestimated 2 cases of T staging,1 case of N staging and 1 case of M staging.18F-FDG PET/CT underestimated 1 case of N staging and 1 case of M staging.18F-FDG PET/CT overestimated 7 cases of N staging and 1 case of M staging.Conclusion The detection ability of 68Ga-FAPI PET/CT for head and neck tumors was comparable to that of 18F-FDG PET/CT.The detection rates of lymph node metastasis and distant metastasis were lower than those of 18F-FDG PET/CT.However,68Ga-FAPI PET/CT reduced the detection of false-positive lymph nodes.68Ga-FAPI PET/CT has a higher accuracy for T-staging,N-staging and M-staging comparing to 18F-FDG PET/CT.关键词
成纤维细胞激活蛋白抑制剂/正电子发射断层显像术/头颈部肿瘤/镓放射性核素/氟代脱氧葡萄糖Key words
fibroblast activating protein inhibitor/positron emission tomography/head and neck tumors/Gallium radionuclide/fluorodeoxyglucose
