分子影像学杂志2023，Vol.46Issue(6)：983-988,6.DOI:10.12122/j.issn.1674-4500.2023.06.05
基于连边分析针刺治疗膝骨性关节炎患者的静息态脑功能连接
Resting-state brain function connectivity in patients with knee osteoarthritis treated with acupuncture based on continuous edge analysis
摘要
Abstract
Objective To explore the changes of the rest brain at rest functional connectivity in patients with knee osteoarthritis(KOA)after acupuncture treatment,so as to provide neuroimaging basis for clinical acupuncture treatment of KOA.Methods Twenty-five patients with KOA were enrolled in the study and treated with acupuncture for 3 weeks.The points of Dubi,Xuehai,Yanglingquan,Zusanli,Sanyinjiao,Neixiyan and Liangqiu group were selected for compatibility,5 times a week,30 minutes each time.The data of visual analogue scale(VAS),knee joint function scale(KSS)and resting state functional MRI of KOA patients before and after acupuncture were collected,and the changes of functional connectivity of various brain regions in KOA patients after acupuncture were described with the method of edge linking analysis,and the correlation analysis was made with the clinical scores.Results After acupuncture treatment,VAS score of KOA patients decreased significantly and KSS score increased significantly(P<0.001).Edge linking analysis showed that after acupuncture,functional connectivity of the right orbital inferior frontal gyrus and the left fusiform gyrus,the right angular gyrus and the left anterior cuneiform lobe,the right anterior central gyrus,the left insular inferior frontal gyrus and the left thalamus,the left posterior central gyrus and the right angular gyrus,and the right superior temporal gyrus were enhanced in KOA patients(P<0.001).Correlation analysis showed that the changes of functional connectivity in right angular gyrus and right anterior central gyrus(r=0.540,P=0.008),left posterior central gyrus and right superior temporal gyrus(r=0.654,P=0.001)were positively correlated with the changes of VAS.Conclusion Acupuncture may relieve pain and improve knee joint movement disorder in KOA patients by positively activating functional connections in some brain regions and strengthening connections between central analgesia regions.These brain regions are mainly distributed in the default mode network,sensorimotor network and cingulate island network.关键词
膝骨性关节炎/针刺/静息态功能磁共振成像/连边分析/脑功能连接Key words
knee osteoarthritis/scupuncture/resting state functional magnetic resonance imaging/edge connection analysis/brain functional connectivity引用本文复制引用
李文博,马萧童,张聪,郑运松,王志群,李鹏,魏伟,康武林..基于连边分析针刺治疗膝骨性关节炎患者的静息态脑功能连接[J].分子影像学杂志,2023,46(6):983-988,6.基金项目
陕西省中医药管理局中医药科研项目(SZY-KJCYC-2023-024) （SZY-KJCYC-2023-024）
咸阳市科技局重点研发计划项目(S2023-ZDYF-SF-1756) （S2023-ZDYF-SF-1756）
陕西中医药大学陕西省针药结合重点实验室项目(KF202320) （KF202320）
陕西省卫生健康委卫生健康科研项目(2021D037) （2021D037）
北京中医药大学孙思邈研究院中医药科研项目(SSMYJY-2-2021-16) （SSMYJY-2-2021-16）
咸阳市脑功能磁共振成像技术临床研究创新团队支持项目(2020CXTD002) （2020CXTD002）
