分子影像学杂志2023，Vol.46Issue(6)：994-1000,7.DOI:10.12122/j.issn.1674-4500.2023.06.07
非小细胞肺癌CT影像特征与Ki-67、血管内皮生长因子表达的关系
Relationship between CT imaging features of non-small cell lung cancer and expression of Ki-67 and vascular endothelial growth factor
摘要
Abstract
Objective To explore the relationship between CT imaging features of non-small cell lung cancer(NSCLC)and the expression of Ki-67 and vascular endothelial growth factor(VEGF),providing a theoretical basis for the clinical diagnosis,treatment,and prognosis of NSCLC.Methods A retrospective analysis of 112 patients diagnosed with NSCLC in our hospital from January 2018 to January 2023.Philips Brilliance 256iCT was used to examine CT imaging features,and the expression of Ki-67 and VEGF in NSCLC tissues was detected.The relationship between imaging features,clinical data(pathological type,gender,age,smoking history),Ki-67 and VEGF expression levels was analyzed.Results In the relationship between CT features and Ki-67 expression,the presence of spiculation sign,deep lobulation sign,arterial phase enhancement CT value≥20 Hu,venous phase enhancement CT value≥20 Hu,enlargement of mediastinal lymph nodes and diameter≥3 cm was associated with a high Ki-67 positive expression rate(P<0.05).The presence of calcification and pleural traction sign was associated with a low Ki-67 positive expression rate(P<0.05).Other indicators showed no statistical significance.In the relationship between CT features and VEGF expression,the presence of vessel convergence sign,significant enhancement in the arterial phase≥20 Hu,diameter≥3 cm,and enlargement of mediastinal lymph nodes was associated with a high VEGF positive expression rate(P<0.05).The presence of air bronchogram sign,deep lobulation sign,and diameter<3 cm was associated with a low VEGF positive expression rate(P<0.05).In the relationship between clinical data and Ki-67 and VEGF expression,males,those with a smoking history,and a high Ki-67 positive expression rate in patients,and a low Ki-67 positive expression rate in squamous cell carcinoma,were statistically significant(P<0.05).There was no statistical difference in VEGF expression between different clinical data groups(P>0.05).Conclusion CT imaging features in NSCLC patients are closely related to the expression of Ki-67 and VEGF,providing a certain predictive value for immunohistochemical marker expression.关键词
CT特征/非小细胞肺癌/Ki-67/血管内皮生长因子Key words
CT features/non-small cell lung cancer/Ki-67/vascular endothelial growth factor引用本文复制引用
杨奎,徐鹏,田佳明,王汉卿..非小细胞肺癌CT影像特征与Ki-67、血管内皮生长因子表达的关系[J].分子影像学杂志,2023,46(6):994-1000,7.基金项目
黑龙江省教育科学"十四五"规划2022年度课题(GJB1422722) （GJB1422722）
