分子影像学杂志2023，Vol.46Issue(6)：1102-1106,5.DOI:10.12122/j.issn.1674-4500.2023.06.25
体积测量法在非小细胞肺癌患者非手术治疗疗效评估中的应用价值
Application value of the volumetric method in assessing the effectiveness of nonoperative treatment for patients with non-small cell lung cancer
张玉文 1王雪莲 1顾长青 1孙冬雪 1张志雅 1王伟 1沈俊杰1
作者信息
- 1. 蚌埠医学院第一附属医院放射科,安徽 蚌埠 233000
- 折叠
摘要
Abstract
Objective To analyze whether tumor volume and tumor maximum diameter[based on the criteria for evaluating the efficacy of solid tumors(RECIST)version 1.1]are correlated with each other in evaluating patients with advanced non-small cell lung cancer(NSCLC)after non-surgical treatment and to assess the value of the application of the changes in tumor volume of advanced NSCLC in the evaluation of efficacy.Methods We retrospectively analyzed the CT imaging data of 108 patients with pathologically confirmed NSCLC by puncture biopsy and followed them up,measured the volume of the lesions before and after treatment using volumetric software,recorded the volume measurement values with the maximum diameter of the lesions,and then evaluated the therapeutic efficacy by the volumetric method and RECIST version 1.1,respectively.The complete response and partial response were categorized into the partial responders,and stable disease and progressive disease were categorized into the non-responders according to different criteria.Spearman correlation coefficients were used to assess the correlation between the maximum diameter of RECIST and the rate of change in volume before and after treatment,and Kaplan-Meier curves were used to evaluate the association between the survival of patients in different evaluation criteria.Results The rate of change of volume versus diameter relative to baseline measurements was calculated by baseline and first follow-up scans,and the assessment showed a moderate correlation(r=0.881,P<0.01).The difference between the Kaplan-Meier curves of the responders and non-responders as assessed by the volume criterion at first follow up was statistically significant(P=0.002),and the difference between the two groups was not statistically significant when assessed according to the RECIST criterion(P=0.828).Conclusion Volumetric measurements have good application value for the assessment of the efficacy of NSCLC after treatment.关键词
肺癌/非小细胞肺癌/体积测量/RECIST疗效评估Key words
lung cancer/non-small cell lung cancer/volume measurement/RECIST efficacy evaluation引用本文复制引用
张玉文,王雪莲,顾长青,孙冬雪,张志雅,王伟,沈俊杰..体积测量法在非小细胞肺癌患者非手术治疗疗效评估中的应用价值[J].分子影像学杂志,2023,46(6):1102-1106,5.
