分子影像学杂志2023，Vol.46Issue(6)：1112-1117,6.DOI:10.12122/j.issn.1674-4500.2023.06.27
骨组织库技术保存自体颅骨在颅骨缺损修补术中的临床疗效及安全性观察
Observation of the clinical efficacy and safety of autologous bone preserved using bone tissue bank technology in cranioplasty
摘要
Abstract
Objective To observe the clinical efficacy and safety of autogenous skull preserved by bone tissue bank technology in cranioplasty.Methods Hospitalized patients with supratentorial skull defect repair surgery in the Department of Neurosurgery,Shunde Hospital of Southern Medical University from September 2019 to July 2022 were enrolled.According to different repair materials,the patients were divided into the autologous skull repair group(n=30,autologous skull repair surgery preserved by bone tissue bank)and the 3D titanium mesh group(n=30,skull repair surgery with 3D digital shaped titanium mesh).The general data of the two groups was comparable(P>0.05).Indicators of complications directly related to surgery including infection rate within 1 month after surgery,incidence of epidural effusion/hematoma,incidence of poor healing of surgical incision,epilepsy incidence and incidence of intracerebral hemorrhage were compared between the two groups and bone absorptivity based on skull CT images was measured in the autologous skull repair group.Results Both groups were followed up for at least 6 months after surgery.There was no significant difference in the infection rate within 1 month after surgery(0 case vs 0 case),incidence of epidural effusion/hematoma(3 cases vs 7 cases),incidence of poor healing of surgical incision(0 case vs 0 case),epilepsy incidence(0 case vs 0 case)and incidence of intracerebral hemorrhage(0 case vs 1 case)between the autologous skull group and 3D titanium mesh group(P>0.05).Bone resorption occurred in 4 patients(13.3%)in the autogenous skull group 6 months after operation,and one of the patients with severe bone resorption required re-repair with artificial materials.There was no significant difference in the total complication rate between the autologous skull group and 3D titanium mesh group[7 cases(23%)vs 8 cases(35%),P>0.05].Conclusion The technique of preserving autogenous skull through bone tissue bank is one of the safe and effective methods in cranioplasty while remaining a risk of bone resorption,it can be an alternative depending on the specific situation of patients clinically.关键词
颅骨缺损/颅骨成形术/自体颅骨Key words
skull defect/cranioplasty/autologous bone引用本文复制引用
卢乐年,许小兵,陈达良,邱胜聪,马立毅,仇尔宁,池雅杰,林继业,郑大海..骨组织库技术保存自体颅骨在颅骨缺损修补术中的临床疗效及安全性观察[J].分子影像学杂志,2023,46(6):1112-1117,6.基金项目
佛山市科技创新项目自筹经费类科技计划项目(2020001005045) （2020001005045）
广东省重点领域研发计划项目(2018B090906001) （2018B090906001）
广东省"十四五"医学临床重点专科建设项目 （）
佛山市"十四五"医学高水平重点专科项目(FSGSP145099) （FSGSP145099）
