国际妇产科学杂志2023，Vol.50Issue(6)：689-694,6.DOI:10.12280/gjfckx.20230679
子痫前期母胎界面TLR4作用的研究进展
Research Progress into the Role of TLR4 at the Maternal-Fetal Interface in Pre-Eclampsia
摘要
Abstract
Pre-eclampsia is a pregnancy complication with multiple organs and system injuries,seriously impairing maternal and fetal health.Nevertheless,the etiopathogenesis of pre-eclampsia has not been fully elucidated yet.In normal pregnancy,Toll-like receptor 4(TLR4)at the maternal-fetal interface regulates the homeostasis of the inflammatory-immune microenvironment.In pre-eclampsia,abnormal TLR4 signaling at the maternal-fetal interface not only mediates deviated inflammatory-immune reaction,but also interacts with other novel pathological phenomena,including ferroptosis,pyroptosis,metabolism reprogramming,and cellular senescence.Furthermore,TLR4 at the maternal-fetal interface may mediate the abnormal development of the nervous system in the offspring.In addition,targeting TLR4 at the maternal-fetal interface may be one of the potential pharmacological mechanisms for new therapeutic research in pre-eclampsia.Based on recent relevant literature,this article explores the multiple possible roles of TLR4 at the maternal-fetal interface in pre-eclampsia and provides reference for the study of the pathogenesis and therapies of pre-eclampsia.关键词
先兆子痫/Toll样受体4/母体胎儿间交换/炎症/炎症趋化因子类/母胎界面Key words
Pre-eclampsia/Toll-like receptor 4/Maternal-fetal exchange/Inflammation/Chemokines/Maternal-fetal interface引用本文复制引用
黄晓彤,程湘玮,张阳..子痫前期母胎界面TLR4作用的研究进展[J].国际妇产科学杂志,2023,50(6):689-694,6.基金项目
湖北省自然科学基金(2021CFB593) （2021CFB593）
