国际妇产科学杂志2023，Vol.50Issue(6)：695-698,4.DOI:10.12280/gjfckx.20230594
雌激素受体信号通路与子痫前期的关系
The Relationship between Estrogen Receptor Signaling Pathway and Pre-Eclampsia
摘要
Abstract
Pre-eclampsia(PE)is a pregnancy specific syndrome characterized by hypertension and multiple organ dysfunction.Although the specific pathogenesis is not yet clear,insufficient placental perfusion and persistent hypoxia caused by shallow and limited invasion of trophoblasts during placental formation may be important initial events.As an important steroid hormone secreted by the placenta,estrogen regulates target gene expression levels through genomic or non-genomic effects of estrogen receptor(ER)and estrogen response element(ERE)signaling pathways,leading to changes in biological behaviors such as trophoblast proliferation,apoptosis,invasion,and possibly mediating the loss of endometrial decidualization,thereby participating in placental shallow implantation and the occurrence of insufficient perfusion.Estrogen and its signaling pathways can also regulate the levels of vasoactive factors such as nitric oxide and the activity of related ion channels to regulate the contractile and relaxing ability of uterine artery smooth muscle,and participate in the occurrence and development of high-risk pregnancies such as PE and recurrent spontaneous abortion through various mechanisms.关键词
先兆子痫/雌激素类/受体,雌激素/信号通路/发病机制Key words
Pre-eclampsia/Estrogens/Receptors,estrogen/Signaling pathway/Pathogenesis引用本文复制引用
胡悦,盛红娜,梁美育,范卓然,华绍芳..雌激素受体信号通路与子痫前期的关系[J].国际妇产科学杂志,2023,50(6):695-698,4.基金项目
天津医科大学第二医院青年科研基金(2021ydey06) （2021ydey06）
