广西医学2023，Vol.45Issue(19)：2301-2304,2330,5.DOI:10.11675/j.issn.0253-4304.2023.19.01
血清hs-CRP、Hcy联合颈动脉超声参数在冠心病患者冠状动脉狭窄程度评估中的应用价值
Application value of serum hs-CRP and Hcy combined with carotid ultrasound parameters in the evaluation of coronary artery stenosis degree in patients with coronary heart disease
摘要
Abstract
Objective To investigate the application value of serum high-sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)combined with carotid ultrasound parameters in the evaluation of coronary artery stenosis degree in patients with coronary heart disease.Methods A total of 98 patients with coronary artery disease were divided into mild stenosis group(Gensini score<20,n =32)or moderate-severe stenosis group(Gensini score≥20,n =66)according to Gensini score.The general data,serum hs-CRP level,serum Hcy level,carotid intima-media thickness(IMT),and carotid plaque Crouse score were compared between patients of the two groups.The correlation of serum hs-CRP level,serum Hcy level,and carotid ultrasound parameters with the degree of coronary artery stenosis was analyzed by using Spearman correlation method.The receiver operating characteristic(ROC)curve was used to analyze the efficiency of serum hs-CRP and Hcy levels,and carotid ultrasound parameters for alone and jointly evaluating moderate-severe coronary artery stenosis.Results Serum hs-CRP and Hcy levels,carotid plaque Crouse score,and carotid IMT in the moderate-severe stenosis group were higher than those in the mild stenosis group(P<0.05).The results of Spearman correlation analysis revealed that serum hs-CRP and Hcy levels,carotid plaque Crouse score,and carotid IMT positively correlated with the degree of coronary artery stenosis(P<0.05).The results of ROC curve analysis indicated that areas under the curve of serum hs-CRP and Hcy levels,carotid plaque Crouse score,carotid IMT for alone and jointly evaluating moderate-severe coronary artery stenosis were 0.847,0.768,0.884,0.783,and 0.986,respectively.Conclusion Serum hs-CRP and Hcy levels,carotid plaque Crouse score,and carotid IMT correlate with the degree of coronary artery stenosis in patients with coronary heart disease,and these indicators exert a predictive value on moderate-severe coronary artery stenosis to a certain extent,and the combined evaluation exerts a relatively higher predictive value.关键词
冠心病/冠状动脉/狭窄/超敏C-反应蛋白/同型半胱氨酸/颈动脉超声/预测价值Key words
Coronary heart disease/Coronary artery/Stenosis/High-sensitivity C-reactive protein/Homocysteine/Carotid ultrasound/Predictive value分类
医药卫生引用本文复制引用
付瑶,张媛媛,聂颖,孔令伟,刘红军,张菡,郭添元..血清hs-CRP、Hcy联合颈动脉超声参数在冠心病患者冠状动脉狭窄程度评估中的应用价值[J].广西医学,2023,45(19):2301-2304,2330,5.基金项目
北京交通大学基本科研项目(2023JBZX020) （2023JBZX020）
