广西医学2023，Vol.45Issue(19)：2325-2330,6.DOI:10.11675/j.issn.0253-4304.2023.19.06
预后营养指数和系统免疫炎症指数与肾透明细胞癌患者预后的关系
Relation of prognostic nutritional index and systemic immune-inflammation index with prognosis of patients with clear cell carcinoma of kidney
摘要
Abstract
Objective To investigate the value of preoperative prognostic nutritional index(PNI)and systemic immune-inflammation index(SII)for predicting postoperative prognosis of patients with clear cell carcinoma of kidney.Methods The clinical data of 263 patients with clear cell carcinoma of kidney were retrospectively analyzed,and they were assigned to death group or survival group according to patients′prognosis.The preoperative PNI,SII,and general clinical data were compared between patients of the two groups.The risk factors for affecting postoperative prognosis in patients with clear cell carcinoma of kidney were analyzed by employing the COX regression model.The efficiency of preoperative PNI and SII for predicting postoperative prognosis in patients with clear cell carcinoma of kidney was analyzed by using the receiver operating characteristic(ROC)curve.Results The death group exhibited a higher preoperative SII,a lower preoperative PNI as compared with the survival group(P<0.05).There were statistically significant differences in age,body mass index,clinical symptom conditions,hemoglobin level,platelet counts,lymphocyte counts,neutrophil counts,serum albumin level,serum creatinine level,TNM stage,operative methods,and tumor necrosis between the death group and the survival group(P<0.05).The results of multivariate COX regression analysis indicated that high preoperative PNI was the protective factor for postoperative prognosis in patients with clear cell carcinoma of kidney,whereas high preoperative SII,relatively high T stage and M stage were its risk factors(P<0.05).The results of ROC curve analysis interpreted that areas under the curve of preoperative SII and PNI for alone and jointly predicting postoperative prognosis in patients with clear cell carcinoma of kidney were 0.775,0.783,and 0.829,respectively,the sensitivities were 65.9%,70.7%,and 73.2%,respectively,and the specificities were 81.5%,75.2%,and 85.6%,respectively.Conclusion High preoperative PNI is the protective factor for postoperative prognosis in patients with clear cell carcinoma of kidney,while high preoperative SII,relatively high T stage and M stage are the risk factors for postoperative prognosis in patients with clear cell carcinoma of kidney.Preoperative SII and PNI exert prediction efficiency on postoperative prognosis in patients with clear cell carcinoma of kidney to a certain extent,and the combined prediction of the two interprets superior efficiency.关键词
肾透明细胞癌/预后营养指数/系统免疫炎症指数/预后/预测效能Key words
Clear cell carcinoma of kidney/Prognostic nutritional index/Systemic immune-inflammation index/Prognosis/Prediction efficiency分类
医药卫生引用本文复制引用
麻玲霞,黄遐,徐永荣,李燕..预后营养指数和系统免疫炎症指数与肾透明细胞癌患者预后的关系[J].广西医学,2023,45(19):2325-2330,6.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210991) （Z20210991）
