广西医学2023，Vol.45Issue(19)：2343-2348,6.DOI:10.11675/j.issn.0253-4304.2023.19.09
血府逐瘀汤联合穴位针刺治疗对急性心肌梗死患者缺血再灌注损伤及血清炎症因子水平的影响
Effect of Xuefu Zhuyu Decoction combined with acupoint acupuncture therapy on ischemia reperfusion injury and serum inflammatory factors levels in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the effect of Xuefu Zhuyu Decoction combined with acupoint acupuncture therapy on ischemia reperfusion injury and serum inflammatory factors levels in patients with acute myocardial infarction(AMI).Methods Ninety patients with AMI were randomly divided into combination group or control group,with 45 cases in each group.On the basis of conventional symptomatic treatment,the control group received acupoint acupuncture for treatment,whereas the combination group was treated with Xuefu Zhuyu Decoction combined with acupoint acupuncture.The total clinical effective rate,and pre-and post-treatment Traditional Chinese Medicine syndrome score,myocardial injury indices levels,serum inflammatory factors levels,changes of indices related to 24-hour dynamic electrocardiogram were compared between patients of the two groups;furthermore,the occurrence of adverse reactions during treatment was statistically analyzed in the two groups.Results The total clinical effective rate in the combination group(91.11%)was higher than that in the control group(73.33%,P<0.05).After treatment,the scores of chest pain,chest distress,shortness of breath,palpitation,fatigue and weariness,and the total score of Traditional Chinese Medicine syndromes,serum cardiac troponinⅠ,creatine kinase isoenzyme,N-terminal pro-B-type natriuretic peptide,interleukin 6,high-sensitivity C-reactive protein,and tumor necrosis factor α levels,as well as the frequency of ischemic attack within 24 hours,decreased amplitude and duration of ST segment in the two groups were decreased or reduced as compared with before treatment;moreover,the combination group yielded lower or less aforementioned indices as compared with the control group(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions during treatment between patients of the two groups(P>0.05).Conclusion On the basis of conventional symptomatic treatment,employing Xuefu Zhuyu Decoction combined with acupoint acupuncture therapy can improve AMI patients′clinical efficacy,ameliorate clinical symptoms in terms of chest pain,chest distress,shortness of breath,palpitation,fatigue and weariness,etc.,decrease levels of myocardial injury indices and serum inflammatory factors in patients,ameliorate indices related to 24-hour dynamic electrocardiogram,exerting protective effect on ischemia reperfusion injury,with relatively high safety,and it is worthy of application and promotion.关键词
急性心肌梗死/血府逐瘀汤/穴位针刺/缺血再灌注损伤/炎症因子Key words
Acute myocardial infarction/Xuefu Zhuyu Decoction/Acupoint acupuncture/Ischemia reperfusion injury/Inflammatory factors分类
医药卫生引用本文复制引用
张丽,华东平,汪远军,谢菁,李春芳..血府逐瘀汤联合穴位针刺治疗对急性心肌梗死患者缺血再灌注损伤及血清炎症因子水平的影响[J].广西医学,2023,45(19):2343-2348,6.基金项目
安徽省卫生和计划生育委员会中医药科研课题(2016zy100) （2016zy100）
