海南医学院学报2023，Vol.29Issue(24)：1889-1898,10.DOI:10.13210/j.cnki.jhmu.20231008.002
高尿酸血症对经皮冠状动脉介入术后发生造影剂相关急性肾损伤影响的meta分析
Meta-analysis of the impact of hyperuricemia on contrast agent-related acute kidney injury after percutaneous coronary intervention
摘要
Abstract
Objective:To evaluate the impact of hyperuricemia on the occurrence of contrast agent-related acute kidney in-jury after percutaneous coronary intervention.Methods:Retrieve PubMed,Embase,Cochrane Library,Web of Science,CNKI,Wanfang,and VIP databases,and publish articles on the correlation between hyperuricemia and contrast agent-related acute kid-ney damage after percutaneous coronary intervention from the establishment of the database to August 16,2023.Two researchers independently conducted literature screening and data extraction to evaluate the bias risk of inclusion in the study,and conducted meta-analysis using Review Manager 5.4 software.Results:A total of 12 articles were included,including 11 676 patients.The meta-analysis results showed that compared with patients without hyperuricemia,patients with hyperuricemia had a higher risk of developing PC-AKI,with an incidence rate of 22.3%.Hyperuricemia was a risk factor for the occurrence of PC-AKI(OR=2.03,95%CI:1.58-2.61);Patients with hyperuricemia have a higher risk of death after PC-AKI,with a mortality rate of 7.5%.Hyper-uricemia is a risk factor for early death in PC-AKI patients(OR=2.33,95%CI:1.81-3.00);The probability of CRRT treatment after PC-AKI in patients with hyperuricemia is higher,at 3.14%.Hyperuricemia is an influencing factor for CRRT treatment in PC-AKI patients(OR=7,95%CI:2.83-17.30).Conclusion:Existing research evidence suggests that the presence of hyperuricemia is an independent risk factor for the occurrence of PC-AKI,and it significantly increases the hospital mortality rate and the risk of renal replacement therapy in PC-AKI patients.关键词
高尿酸血症/冠状动脉介入/造影剂相关/急性肾损伤/meta分析Key words
Hyperuricemia/Coronary artery intervention/Contrast agent-related/Acute kidney injury/Meta analysis分类
医药卫生引用本文复制引用
姚志,史月欣,孙鲁英..高尿酸血症对经皮冠状动脉介入术后发生造影剂相关急性肾损伤影响的meta分析[J].海南医学院学报,2023,29(24):1889-1898,10.基金项目
This study was supported by the Key Research and Development Program of the Ministry of Science and Technology(2018YFC1704304) 国家科学与技术部重点研发计划(2018YFC1704304) （2018YFC1704304）
