河北医学2023，Vol.29Issue(12)：1962-1967,6.DOI:10.3969/j.issn.1006-6233.2023.12.06
NLRC3参与的肿瘤免疫机制在子宫内膜异位症发病中的作用
The Role of NLRC3 in the Tumor Immune Mechanism Involved in the Pathogenesis of Endometriosis
摘要
Abstract
Objective:To explore the expression of Nucleotide-binding Oligomerization Domain(NOD)-like receptor family CARD domain-containing protein 3(NLRC3)in ovarian ectopic endometrial tissues of stage Ⅲ and Ⅳ endometriosis(EMT)patients and its relationship with clinical pathological features.Meth-ods:Immunohistochemistry,Western Blot,and qRT-PCR were used to detect the expression of NLRC3 in 17 cases of stage Ⅲ,17 cases of stage Ⅳ ovarian ectopic endometrial tissues,and 17 cases of normal endometrial tissues.The relationship between NLRC3 and clinical pathological features of EMT patients was analyzed.Re-sults:Compared with normal endometrial tissues,the expression level of NLRC3 was decreased in stage Ⅲ and stage Ⅳ ectopic endometrial tissues(P<0.05),while there was no statistically significant difference in NLRC3 expression between stage Ⅲ and stage Ⅳ endometriosis patients(P>0.05).The positive rate of NL-RC3 protein expression was lower in patients with higher CA125 levels(P<0.05).There was no statistically significant difference in NLRC3 expression among EMT patients of different ages,lesion sizes,and degrees of dysmenorrhea(P>0.05).Conclusion:The pathogenesis of EMT is associated with immune imbalance in the peritoneal microenvironment,and the decreased or lost immune surveillance function of NLRC3 may be in-volved in the occurrence and development of EMT.The combined detection of CA125 and NLRC3 expression may play a significant role in predicting or diagnosing EMT.关键词
子宫内膜异位症/NLRC3/免疫监视/CA125Key words
Endometriosis/NLRC3/Immune surveillance/CA125引用本文复制引用
郝梦启,姬佩雲,高秀娟,庄新荣,张桂香,张雅丽..NLRC3参与的肿瘤免疫机制在子宫内膜异位症发病中的作用[J].河北医学,2023,29(12):1962-1967,6.基金项目
河北省2020年度医学科学研究课题计划,(编号:20200393) （编号:20200393）
