河北医学2023，Vol.29Issue(12)：1973-1978,6.DOI:10.3969/j.issn.1006-6233.2023.12.08
2型糖尿病合并结直肠癌患者癌组织中Ras ERK1/2蛋白表达及意义
Ras and ERK1/2 Protein Expression in Cancer Tissues of Patients with Type 2 Diabetes Mellitus and Colorectal Cancer:Significance and Correlation with Lymph Node Metastasis and Survival
摘要
Abstract
Objective:To investigate the expression levels of Ras-ERK1/2 signaling in patients with type 2 diabetes mellitus(T2DM)and colorectal cancer(CRC),analyze their relationship with lymph node metastasis,and explore their correlation with survival status.Methods:A total of 59 patients who underwent colorectal cancer surgery at People's Hospital of Shijiazhuang from March 2019 to January 2021 were selected.Patients were divided into the diabetes group(n=29)and non-diabetes group(n=30)based on the pres-ence of concurrent diabetes.Immunohistochemical methods were used to detect the expression levels of Ras and ERK1/2 proteins in surgically resected cancer tissues.Differences in lymph node metastasis were analyzed using the Log-rank test.All patients were followed up for 36 months,and survival conditions were statistically compared.The Spearman correlation analysis was used to analyze the correlation between Ras and ERK1/2 expression and survival period.Results:Ras and ERK1/2 were expressed in both CRC and CRC combined with T2DM,mainly concentrated in the cytoplasm of cancer cells.Compared with the non-diabetes group,the positive expression rates of Ras and ERK1/2 in the CRC combined with T2DM group were significantly in-creased(P<0.05).The lymph node metastasis rate in the CRC combined with T2DM group was significantly higher than that in the pure CRC group(P<0.05).Compared with the Ras and ERK1/2 negative expression group,the lymph node metastasis rate was significantly higher in the Ras and ERK1/2 positive expression group(P<0.05).The Spearman correlation analysis showed that the protein expression of Ras and ERK1/2 in colorectal cancer patients was negatively correlated with median survival time(P<0.05).Conclusion:Positive expression of Ras-ERK1/2 proteins is positively correlated with lymph node metastasis and negatively correlated with the survival period of colorectal cancer patients,making it an important target for early diagno-sis and prognosis assessment.关键词
2型糖尿病/结直肠癌/细胞外信号调节激酶1/2蛋白/RasKey words
Type 2 diabetes mellitus/Colorectal cancer/Extracellular signal-regulated kinase 1/2 protein/Ras引用本文复制引用
牛姝,董丽娜,吴笛,冯岚,张梦瑶,孙政,赵志刚,郝慧斌..2型糖尿病合并结直肠癌患者癌组织中Ras ERK1/2蛋白表达及意义[J].河北医学,2023,29(12):1973-1978,6.基金项目
2019年度河北省医学科学研究重点课题计划,(编号:20190161) （编号:20190161）
