河北医学2023，Vol.29Issue(12)：1978-1985,8.DOI:10.3969/j.issn.1006-6233.2023.12.09
老年严重失代偿期急性心力衰竭外周血NRG-1 NT-proBNP CRP水平变化及与预后的关系
Changes in Peripheral Blood NRG-1 NT proBNP CRP Levels and Their Relationship with Prognosis in Elderly Patients with Severe Decompensated Acute Heart Failure
摘要
Abstract
Objective:To investigate the changes of peripheral blood Neuromodulation protein 1(NRG-1),N-terminal pro B-type natriuretic peptide(NT proBNP),C-reactive protein(CRP)levels in elderly patients with severe decompensated acute heart failure and their relationship with prognosis.Methods:A total of 128 elderly patients with severe decompensated acute heart failure who were treated in our hospital from Jan-uary 2021 to February 2022 were selected as the observation group,while 100 patients with chronic heart fail-ure were selected as the control group,the levels of peripheral blood NRG-1,NT-proBNP,and CRP were compared between the two groups.The differences in peripheral blood NRG-1,NT-proBNP,and CRP levels among patients with different clinical characteristics in the observation group were analyzed,as well as the differences in clinical characteristics and peripheral blood NRG-1,NT-proBNP levels and CRP levels of dead and surviving patients.Results:The peripheral blood NRG-1 of the observation group was(936.61±204.40)pg/ml,which was significantly lower than that of the control group(P<0.05),while NT proBNP and CRP were(3611.88±505.52)pg/ml and(28.77±8.05)mg/L,respectively,which was significantly higher than that of the control group(P<0.05).The peripheral blood NRG-1 of NYHA grade IV patients in the ob-servation group was(1106.65±210.41)pg/ml,which was significantly lower than the control group(P<0.05),while NT proBNP and CRP were(3410.45±541.15)pg/ml and(24.40±9.94)mg/L,respectively,which was significantly higher than the control group(P<0.05).The peripheral blood NRG-1 of patients with LVEF<40%in the observation group was(1014.46±201.45)pg/ml,which was significantly lower than that of patients with LVEF≥40%(P<0.05),while NT proBNP and CRP were(3521.08±500.78)pg/ml and(25.71±8.38)mg/L,respectively,which was significantly higher than those of patients with LVEF>40%(P<0.05).Peripheral blood NRG-1 was positively correlated with LVEF(r=0.477,P<0.05),while NT proBNP and CRP levels were negatively correlated with LVEF(r=-0.398 and-0.466,P<0.05).The proportion of dead patients aged≥80 years,the proportion of NYHA grade IV patients,and the proportion of LVEF<40%in the observation group were 70.00%,65.00%,and 85.00%,respectively,which were signifi-cantly higher than those of surviving patients(P<0.05).The peripheral blood NRG-1 of the observation group's deceased patients was(924.54±194.65)pg/ml,which was significantly lower than that of the survi-ving patients(P<0.05),while the levels of NT-proBNP and CRP were(3681.54±445.54)pg/ml and(27.84±6.15)mg/L,respectively,which was significantly higher than those of the surviving patients(P<0.05).Logistic regression analysis showed that NYHA grading,LVEF,NRG-1,NT proBNP,and CRP were influencing factors for patient mortality(P<0.05).Conclusion:The peripheral blood NRG-1 levels in elder-ly patients with severe decompensated acute heart failure decrease,while the levels of NT-proBNP and CRP increase,are related to the patient's cardiac function grading and LVEF,and are also influencing factors for patient prognosis.关键词
老年人/失代偿期/急性心力衰竭/神经调节蛋白1/N末端B型钠尿肽前体/C反应蛋白/预后Key words
Elderly/Period of loss of compensation/Acute heart failure/Neuromodulation pro-tein 1/N-terminal B-type natriuretic peptide precursor/C-reactive protein/Prognosis引用本文复制引用
代智烈,王栋,李立为,陈昌贵,杨力,刘晶晶..老年严重失代偿期急性心力衰竭外周血NRG-1 NT-proBNP CRP水平变化及与预后的关系[J].河北医学,2023,29(12):1978-1985,8.基金项目
湖北省自然科学基金青年项目,(编号:2019CFB405) （编号:2019CFB405）
武汉市卫健委青年基金,(编号:WX21D35) （编号:WX21D35）
