河北医学2023，Vol.29Issue(12)：1998-2004,7.DOI:10.3969/j.issn.1006-6233.2023.12.012
阿仑膦酸钠在骨质疏松椎体压缩性骨折椎体成形术后应用价值
The Value of Alendronate after OVCF Vertebroplasty
摘要
Abstract
Objective:To investigate the role of alendronate anti-osteoporosis in fracture healing and prevention of re-fracture after vertebroplasty for osteoporotic vertebral compression fracture(OVCF).Meth-ods:A total of 99 patients with OVCF who underwent PVP in our hospital from August 2021 to August 2022 were selected and randomly divided into control group(49 cases)and study group(50 cases).The control group was given basic anti-osteoporosis intervention after surgery,and the study group was given new genera-tion bisphosphonate on the basis of the control group after surgery.The treatment continued 6 months.Postop-erative rehabilitation,pain level(VAS score),lumbar spine function(ODI score,JOA score),bone mineral density,bone turnover indexes[N-terminal mid-portion osteocalcin(N-MID-OT),β-collagen special se-quence(β-CTX),and total type 1 collagen amino-terminal prolongation peptide(T-P1NP)],vertebral sta-bility indexes(height ratio of the injured vertebrae,Cobb's angle of the injured vertebrae),and incidence of re-fracture were compared in the two groups were compared.Results:The fracture healing time and recovery time of the study group were shorter than those of the control group(P<0.05).After 3 and 6 months of treat-ment,VAS,ODI scores and Cobb Angle of injured vertebra in the study group were lower than those in the control group,while JOA scores,height ratio of injured vertebra,Ward triangle and bone density of femoral neck in the study group were higher than those in the control group(P<0.05).The serum levels of N-MID-OT,β-CTX and T-P1NP in the study group were lower than those in the control group after 1 month,3 months and 6 months of treatment(P<0.05).The incidence of refracture in the study group was lower than that in the control group(P<0.05).Conclusion:Alendronate combined with PVP in the treatment of OVCF improves bone metabolism,promotes fracture healing,reduces the incidence of postoperative re-fracture,and has significant advantages in the recovery of patients'lumbar spine function and pain relief.关键词
阿仑膦酸钠/骨质疏松椎体压缩性骨折/椎体成形术/骨折愈合/再骨折Key words
Alendronate sodium/Osteoporotic vertebral compression fracture/Vertebroplasty/Fracture union/Refracture引用本文复制引用
廖丹,钱黎..阿仑膦酸钠在骨质疏松椎体压缩性骨折椎体成形术后应用价值[J].河北医学,2023,29(12):1998-2004,7.基金项目
2022年贵州省卫生健康委科学技术基金项目,(编号:gzwkj2022-383) （编号:gzwkj2022-383）
