河北医学2023，Vol.29Issue(12)：2023-2027,5.DOI:10.3969/j.issn.1006-6233.2023.12.016
T2DM伴慢性牙周炎患者龈沟液中hBD-2 hBD-3 LPS与牙周健康指标的关系
Relationship between Gingival Crevicular Fluid Levels of hBD-2 hBD-3 LPS and Periodontal Health Indicators in Patients with Type 2 Diabetes Mellitus and Chronic Periodontitis
摘要
Abstract
Objective:To explore changes in β-defensins(hBD-2,hBD-3),lipopolysaccharides(LPS)in gingival crevicular fluid(GCF),and their correlation with periodontal health indicators in patients with type 2 diabetes mellitus(T2DM)and chronic periodontitis.Methods:This study,approved by the Med-ical Ethics Committee,included 120 patients diagnosed with T2DM and chronic periodontitis(Group A),120 chronic periodontitis patients without T2DM(Group B),and 120 periodontally healthy individuals without T2DM(Group C),between January 2020 and December 2022.GCF levels of hBD-2,hBD-3,LPS,oral and periodontal health-related indicators,and subgingival bacterial flora were measured.The correlation be-tween hBD-2,hBD-3,LPS,and periodontal health indicators in T2DM patients with chronic periodontitis was analyzed.Results:The GCF levels of hBD-2,hBD-3,and LPS in Groups A,B,and C showed signifi-cant differences(P<0.05).In Group A,hBD-2,hBD-3 were lower than in Groups B and C,while LPS was higher than in Groups B and C.Group B had lower hBD-2,hBD-3 compared to Group C,and higher LPS than Group C(P<0.05).Periodontal parameters including PD,SBI,CAL,GCF in Groups A,B,and C showed significant differences(P<0.05).Group A had higher values than Groups B and C,and Group B had higher values than Group C(P<0.05).The levels of Porphyromonas gingivalis,Aggregatibacter actino-mycetemcomitans,Prevotella intermedia,and Tannerella forsythia in Groups A,B,and C differed significant-ly(P<0.05).Group A had higher levels compared to Groups B and C,and Group B had higher levels com-pared to Group C(P<0.05).Significant negative correlations were found between GCF hBD-2,hBD-3,and PD,SBI,CAL,GCF,while LPS showed a significant positive correlation with these parameters(P<0.05).Conclusion:GCF levels of hBD-2,hBD-3 significantly decrease,and LPS significantly increase in T2DM patients with chronic periodontitis,showing a close relationship with the deterioration of periodontal health in-dicators.关键词
2型糖尿病/慢性牙周炎/龈沟液/β防御素/脂多糖/牙周健康指标/菌群Key words
Type 2 diabetes mellitus/Chronic periodontitis/Gingival crevicular fluid/β-de-fensins/Lipopolysaccharides/Periodontal health indicators/Microbial flora引用本文复制引用
海丽达·马克西,杨芳,艾克热木·木沙..T2DM伴慢性牙周炎患者龈沟液中hBD-2 hBD-3 LPS与牙周健康指标的关系[J].河北医学,2023,29(12):2023-2027,5.基金项目
新疆维吾尔自治区卫生与健康适宜技术推广项目,(编号:SYTG-2021142) （编号:SYTG-2021142）
