河北医学2023，Vol.29Issue(12)：2054-2059,6.DOI:10.3969/j.issn.1006-6233.2023.12.022
YKL-40水平预测慢性阻塞性肺疾病急性加重风险的意义研究
Significance of YKL-40 Levels in Predicting the Risk of Acute Exacerbation in Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective:To explore the significance of chitin enzyme protein 40(YKL-40)and CXC che-mokine ligand 9(CXCL9)in predicting the acute exacerbation risk of chronic obstructive pulmonary disease(COPD).Methods:From October 2019 to October 2021,150 COPD patients(38 females and 112 males)and 150 normal people were selected as the research objects.Serum YKL-40 and CXCL9 levels were meas-ured by ELISA,and the hospitalization time was calculated.Follow up the number of acute exacerbations of COPD within one year after this hospitalization.Results:Compared with the control group,the serum YKL-40 level in COPD patients increased significantly(22.23±15.35 ng/ml vs 63.96±13.66 ng/ml,t=24.79,P<0.0001),while the level of CXCL9 did not change significantly(17.92±9.01 ng/ml vs 19.29±9.84 ng/mL,t= 1.26,P = 0.210).Serum YKL-40 increased with the increase of GOLD grade in COPD patients(grade 1-2:51.82±12.82 ng/ml;Grade 3:63.26±4.59 ng/ml;Grade 4:76.86±7.59 ng/mL,F=96.92,P<0.0001).Compared with COPD patients with mMRC score≤2,the serum YKL-40 level of COPD patients with mMRC score of 2～3 or≥3 was increased(58.35±15.37 ng/ml vs 64.55±10.60 ng/ml,68.79±12.66 ng/mL,P<0.05).In COPD patients,serum YKL-40 was negative correlated with FEV1(r=-0.668,P<0.001)and FEV1/FVC(r=-0.167,P=0.041),and serum YKL-40 was positively correlated with IL-6(r=0.257,P=0.002),TNF-α(r=0.522,P<0.001)and CRP(r=0.231,P=0.006).Compared with COPD patients whose hospitalization time was≤8 d,the serum YKL-40 level of COPD patients whose hospitalization time was 8～13 d and≥13 d was increased(57.31±15.82 ng/ml vs 64.96±9.98 ng/ml,69.79±11.58 ng/mL,P<0.05).The level of serum YKL-40 in patients with acute exacerbation≤2 times was significantly lower than that in patients with acute exacerbation>2 times(58.77±15.66 ng/ml vs 69.58±9.08 ng/ml,t=5.17,P<0.001).Multiple linear regression showed that serum YKL-40 was negatively corre-lated with FEV1%(OR=0.700,95%CI=-0.958,-0.272)and positively correlated with hospitalization time≥13 d(OR=1.125,95%CI=1.007,1.472).Conclusion:The level of serum YKL-40 at admission is positively correlated with the severity and poor prognosis of COPD patients.关键词
甲壳质酶蛋白40/CXC趋化因子配体9/慢性阻塞性肺疾病/急性加重Key words
Chitinase protein 40/CXC chemokine ligand 9/Chronic obstructive pulmonary dis-ease/Acute aggravation引用本文复制引用
何芸,刘霖,韩瑞萍,戴伟,吴艳霞..YKL-40水平预测慢性阻塞性肺疾病急性加重风险的意义研究[J].河北医学,2023,29(12):2054-2059,6.基金项目
湖北省卫生健康科研基金项目,(编号:20210836) （编号:20210836）
