核化学与放射化学2023，Vol.45Issue(6)：477-486,10.DOI:10.7538/hhx.2023.45.06.0477
硼中子俘获治疗靶向硼携带剂4-硼-L-苯丙氨酸患者体内生物分布
Biological Distribution in Patients of Boron Agent 4-Borono-L-Phenylalanine for Boron Neutron Capture Therapy
摘要
Abstract
Boron neutron capture therapy(BNCT)is a binary targeted radiation therapy in which neutron does not directly provide tumor dose.The dose produced by the 10B(n,a)7 Li capture reaction will be deposited in tumor cells by using targeted 10B agents.Therefore,understanding the biological distribution of 10B agents in the blood,tumor and normal tissue is essential for BNCT.4-borono-L-phenylalanine(BPA)is the mainly used 10B agent in BNCT clinical trials worldwide.In order to support and facilitate the preparation of BPA-based BNCT clinical trials,information on the structure,physicochemical properties,cellular uptake mechanisms and human biological distribution of BPA are summarized in this paper.关键词
BNCT/BPA/生物分布Key words
BNCT/BPA/biological distribution分类
核科学引用本文复制引用
祝夏阳,刘彤,张紫竹,刘凯,邵玉军,金从军,赵春元,崇奕峥,郭志滨,孙琪,刘志博..硼中子俘获治疗靶向硼携带剂4-硼-L-苯丙氨酸患者体内生物分布[J].核化学与放射化学,2023,45(6):477-486,10.基金项目
中核集团基础研究项目(CNNC-JCYJ-202214) （CNNC-JCYJ-202214）
中国宝原科研基金(ZHYL-BHY-2021001) （ZHYL-BHY-2021001）
中核医疗核医科技创新项目(ZHYL-ZD-2021003) （ZHYL-ZD-2021003）
