核化学与放射化学2023，Vol.45Issue(6)：487-498,12.DOI:10.7538/hhx.2023.45.06.0487
肿瘤靶向的硼携带剂在硼中子俘获治疗中的应用与发展
Application and Development of Tumor-Targeting Boron Carriers in Boron Neutron Capture Therapy
摘要
Abstract
Boron neutron capture therapy(BNCT)is a promising therapeutic method for malignant tumors and has entered the clinical trials.As a binary cellular accurate therapy,BNCT relies on tumor-targeting boron delivery.It is intriguing for boron delivery design that selective recognization,target,and accumulation are based on specific or differential expression receptors on the tumor cell surface.Several delivery strategies targeting other subcellular organelles have also emerged.Here,we summarized the selection,challenges,and improvement of boron targeting delivery methods in small molecule boron drugs and boron-containing nanoparticles.In the future,new technologies,new methods,and new ideas include target receptors finding via omics,ligands optimization via machine learning,and establishment of modular boron cores based on receptors and ligands libraries,thereby provide great convenience for the development of molecular-targeted boron drugs and multi-targeted boron drugs.关键词
BNCT/肿瘤靶向/硼药/硼携带剂/纳米Key words
BNCT/tumor-targeting/boron agent/boron carrier/nano分类
核科学引用本文复制引用
陈奎,吕林雯,邢更妹..肿瘤靶向的硼携带剂在硼中子俘获治疗中的应用与发展[J].核化学与放射化学,2023,45(6):487-498,12.基金项目
国家自然科学基金(12105312,31971294) （12105312,31971294）
粤莞联合基金(2021B1515120037,2021B1515140042) （2021B1515120037,2021B1515140042）
粤港澳中子散射科学和技术联合实验室开放课题(E1905DHT) （E1905DHT）
