核化学与放射化学2023，Vol.45Issue(6)：524-531,8.DOI:10.7538/hhx.2023.45.06.0524
用于硼中子俘获治疗的碳硼烷多肽衍生物
Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy
摘要
Abstract
The design and application of carborane polypeptide derivatives have attracted more and more attention,especially as boron carrier in the treatment of malignant tumors(BNCT).BNCT uses 10B to react with neutron capture,releasing alpha particles that kill tumor cells.As a binary targeted therapy,the key to its success is the targeting and affinity effect of boron carriers.At present,how to design more efficient boron carriers is the main problem in the development of BNCT.Polypeptides,as biological essential substances,can be taken up specifically by tumors while increasing the targeting of their derivatives,which is a great advantage of carbborane polypeptide compounds as boron carriers.In this paper,the reported carbborane polypeptide derivatives are classified and summarized for the first time,and the development potential as boron carriers for neutron capture therapy is evaluated.The summary of carbborane containing polypeptide derivatives will provide research impetus for the development of a new generation of boron carriers designed for neutron capture therapy.关键词
含碳硼烷多肽衍生物/硼中子俘获治疗/靶向治疗Key words
carborane polypeptide derivatives/BNCT/targeted therapy分类
核科学引用本文复制引用
韩祎,李凤林,罗志福..用于硼中子俘获治疗的碳硼烷多肽衍生物[J].核化学与放射化学,2023,45(6):524-531,8.基金项目
中国原子能科学研究院院长基金(YZ222501001204) （YZ222501001204）
