摘要
Abstract
Boron neutron capture therapy(BNCT),as a highly promising radiotherapy modality,has emerged as a significant treatment option for various malignant tumors,inclu-ding high-grade gliomas,recurrent head and neck cancers,and melanoma.BNCT is charac-terized by the nuclear reactions that occur when nonradioactive 10 B is irradiated by low energy thermal neutron to yield high linear energy transfer(LET)particles,such as 4 He and 7Li.These particles have high relative biological efficacy and a short path length of approximately the diameter of a single cell(5-9 pm),which enables selective damage to tumour cells marked with 10B and preserves the adjacent normal tissue.Compared to classical radiotherapies,BNCT has garnered growing attention within the medical community due to its precision targeting,potent biological effects,and short course of treatment.The therapeutic efficacy of BNCT is based on accurately controlling radiation dose,which is mainly determined by the local 10B concentration of tumour and the neutron flux.Currently,BNCT is being implemen-ted in clinical trials.Dynamic and quantitative monitoring of 10 B concentration of boron-containing drugs in intratumor is the key element to realize the"efficiency and side-effect reduction"of BNCT.Consequently,there is an urgent need for the development of more accurate measurement techniques.In this review,we provide a concise overview of the prin-ciples underlying BNCT,and summarize various monitoring methods for boron-containing drugs during treatment,including physical,nuclear,chemical,and novel techniques utilizing advanced molecular imaging technologies such as positron emission tomography,magnetic resonance imaging,and optical imaging.Furthermore,we analyze the strengths and limita-tions of these approaches.We hope this review provides informative insights into the future development of the precise and efficient BNCT.关键词
硼中子俘获治疗/含硼药物/硼浓度监测/分子影像Key words
boron neutron capture therapy/boron-containing drugs/10B concentration meas-uring/molecular imaging分类
核科学
