中国实用神经疾病杂志2024，Vol.27Issue(1)：20-25,6.DOI:10.12083/SYSJ.230687
DTI对帕金森病认知功能障碍的评估价值
Evaluation value of DTI for cognitive dysfunction in Parkinson's disease
摘要
Abstract
Objective To investigate the evaluation value of magnetic resonance diffusion tensor imaging(DTI)technology on cognitive dysfunction in Parkinson's disease(PD),and to analyze the influencing factors for cognitive impairment related to PD.Methods In the 120 PD patients diagnosed in the First Affiliated Hospital of Nanjing Medical University from January 2021 to December 2022,the Montreal cognitive assessment scale(MoCA)was used to evaluate the cognitive function,and were divided into cognitive dysfunction group(67 cases)and normal cognitive function group(53 cases),which were examined by DTI.The fractional anisotropy(FA)and mean diffusivity(MD)were compared,and the risk factors for cognitive dysfunction were analyzed.Results The FA values of the pallidum and pontons were not statistically significant(P>0.05),and the FA values of the caudate head,substantia nigra and thalamus in the cognitive dysfunction group were significantly lower than those of the normal cognitive function group(P<0.05).Comparison of MD values of globus pallidum,caudate head,pons,substantia nigra,and thalamus was not significant(P>0.05).The years of education in the cognitive dysfunction group were significantly shorter than those in the normal cognitive function group(P<0.05),and the HAMD score,HAMA score,and UPDRS-Ⅲ score were significantly higher in the cognitive dysfunction group than those in the normal cognitive function group(P<0.05).After binary Logistic regression analysis,high HAMA score and high UPDRS-Ⅲ score were risk factors for cognitive impairment(P<0.05),and long years of education was a protective factor for cognitive impairment(P<0.05).Conclusion The FA of caudate nucleus,substantia nigra and thalamus of DTI technology can evaluate the cognitive dysfunction of PD patients,which is related to anxiety,depression and years of education.关键词
帕金森病/磁共振/扩散张量成像/认知功能障碍/影响因素Key words
Parkinson's disease/Magnetic resonance imaging/Diffusion tensor imaging/Cognitive dysfunction/Influencing factors分类
医药卫生引用本文复制引用
褚玉玄,王建伟..DTI对帕金森病认知功能障碍的评估价值[J].中国实用神经疾病杂志,2024,27(1):20-25,6.基金项目
江苏省高校优势学科建设工程资助项目(编号:JX10231801) （编号:JX10231801）
