老年急性脑梗死患者血清Del-1和IL-17水平变化及与梗死面积和预后的关系OACSTPCD

Objective To investigate the relationship of serum developmental endothelial locus-1(Del-1)and interleukin-17(IL-17)levels with the size of cerebral infarction,the severity and the prognosis of elderly patients with acute cerebral infarction(ACI).Methods The clinical data of 126 patients with ACI(case group)treated in the Dongnan Hospital of Xiamen University from January 2019 to December 2021,and 105 healthy people(control group)were retrospectively collected.According to the size of cerebral infarction,patients in the case group were divided into large-area infarction group(maximum diameter＞5 cm,n=14),medium-area infarction group(maximum diameter of 3-5 cm,n=53)and small-area infarction group(maximum diameter＜3 cm,n=59).According to the NIHSS score,the patients were divided into severe group(NIHSS score≥16,n= 13),moderate group(5＜NIHSS score＜15,n=58)and mild group(NIHSS score≤5,n=55).According to the mRS score,the patients were divided into good prognosis group(mRS score≤2,n=81)and poor prognosis group(mRS score＞2,n=45).Serum Del-1 and IL-17 levels were measured by fluorescence immunoassay.The receiver operating characteristic(ROC)curve was used to evaluate the prognostic value of serum Del-1 and IL-17 levels in elderly patients with ACI.Results The proportion of people with smoking history,systolic blood pressure,diastolic blood pressure,glycosylated hemoglobin,and serum IL-17 level in the case group were higher than those in the control group,and serum Del-1 level was lower than that in the control group(P＜0.05).Serum Del-1 level decreased in order,while serum IL-17 level increased in order from the small-area infarction group,the medium-area infarction group to the large-area infarction group(P＜0.05).Serum Del-1 level in the mild group was higher than those in the moderate group and the severe group(P＜0.05).Serum IL-17 level decreased in order from the severe group,the moderate group to the mild disease group(P＜0.05).Serum Del-1 level in the good prognosis group was higher than that in the poor prognosis group,and serum IL-17 level was lower than that in the poor prognosis group(P＜0.05).ROC curve analysis showed that the AUC values of serum Del-1 and IL-17 in the prognosis of patients with ACI were 0.763 and 0.747,respectively(P＜0.05).Conclusion Patients with ACI have relatively low serum Del-1 level and relatively high IL-17 level.The two are closely related to the size,severity and prognosis of ACI.Therefore,they can be used as prognostic factors in elderly patients with ACI.