中国实用神经疾病杂志2024，Vol.27Issue(1)：31-36,6.DOI:10.12083/SYSJ.230889
中重度颅脑创伤患者血清STC1 S100B和NETRIN-1的表达及对预后的预测价值
Expressions of serum STC1,S100B and NETRIN-1 in the patients with moderate to severe traumatic brain injury and predictive value for prognosis
摘要
Abstract
Objective To investigate the expression levels of serum STC1,S100B,and NETRIN-1 in patients with moderate to severe traumatic brain injury(TBI)and the predictive value for the prognosis.Methods The serum sample of 74 patients with TBI and 40 healthy people were collected,and the expression levels of serum STC1,S100B and NETRIN-1 were detected by qRT-PCR before surgery and on 1st,3rd,5th,and 7th day after TBI surgery.The general clinical data of TBI patients were collected.Extended Glasgow outcome scale(EGOS)score was used to evaluate the prognosis and the patients were divided into good prognosis group(EGOS≥5 points,n=40)and poor prognosis group(EGOS<5 points,n=34)according to the EGOS score.The relationship between the expression levels of STC1,S100B,NETRIN-1 and the prognosis of patients was analyzed.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of STC1,S100B,and NETRIN-1 expression levels on the prognosis.Multivariate Logistic analysis was used to evaluate the factors causing poor prognosis in patients with TBI.Results qRT-PCR analysis showed that the expression levels of serum STC1 and S100B in the TBI patients increased before surgery compared with healthy people,while the level of NETRIN-1 decreased.After surgery,serum STC1 and S100B levels decreased,and NETRIN-1 level increased(P＜0.05).The serum levels of STC1 and S100B in TBI patients decreased gradually on 1st,3rd,5th,and 7th day after operation,while the level of NETRIN-1 increased gradually,the most noticeable difference appeared on 5th day after operation(P<0.05).Compared with the patients in good prognosis group on 5th day postoperation,the serum levels of STC1 and S100B in poor prognosis group increased significantly,while the level of NETRIN-1 decreased significantly(P<0.05).Pearson correlation analysis showed that the levels of serum STC1 and S100B in TBI patients on 5th day after surgery were positively proportional to APACHEⅡ score,and the level of NETRIN-1 was inversely proportional to APACHEⅡscore(P＜0.05).ROC curve analysis showed that serum STC1,S100B,and NETRIN-1 levels had predictive value on the prognosis of TBI patients on 5th day after surgery,while multivariate Logistic regression analysis showed that only the level of STC1 was associated with the prognosis of patients(P<0.05).Conclusion The levels of serum STC1,S100B and NETRIN-1 in the patients with TBI expressed abnormally,which has high value for the prognosis analysis of patients with TBI.关键词
颅脑损伤/斯钙素抗体-1/S100钙结合蛋白B/轴突生长诱向因子-1/预后/预测价值Key words
Traumatic brain injury/STC1/S100B/NETRIN-1/Prognosis/Predictive value分类
医药卫生引用本文复制引用
叶俊伟,施丹娜..中重度颅脑创伤患者血清STC1 S100B和NETRIN-1的表达及对预后的预测价值[J].中国实用神经疾病杂志,2024,27(1):31-36,6.基金项目
湖北省卫生健康委2019年度第三批联合基金课题项目(编号:wj2019h461) （编号:wj2019h461）
