中国实用神经疾病杂志2024，Vol.27Issue(1)：48-53,6.DOI:10.12083/SYSJ.231178
颈动脉超声高分辨MRI联合血清miR-27a预测颈动脉支架植入术后抗血小板治疗患者预后的价值
Value of carotid artery ultrasound and high-resolution MRI parameters combined with serum miR-27a in predicting the prognosis of patients with carotid artery stenosis after surgery
摘要
Abstract
Objective To investigate the prognostic value of carotid ultrasound and high-resolution MRI parameters combined with serum miR-27a in predicting the prognosis of patients with carotid artery stenosis after carotid stent implantation.Methods A total of 110 patients with carotid artery stenosis who received carotid stent implantation and postoperative antiplatelet therapy in Daqing Longnan Hospital from January 2021 to December 2022 were included.All subjects were examined by color Doppler ultrasonography before surgery,and the mean flow velocity(MFV),end diastolic velocity(EDV),peak systolic velocity(PSV)and carotid artery stenosis rate were measured and recorded.The plaque eccentricity index and plaque enhancement degree of patients were examined by high-resolution MRI.Serum miR-27a levels were detected by fluorescence quantitative PCR.The patients were followed up for 1 year after discharge to observe their prognosis,and were divided into good prognosis group and bab prognosis group.Results Among the 110 patients,83 had good prognosis and 27 had bab prognosis.There were no significant differences in gender,age,height,weight,smoking history and drinking history between the good prognosis group and the bad prognosis group(P>0.05).PSV,plaque enhancement and serum miR-27a in the good prognosis group were significantly decreased compared with those in the poor prognosis group(P<0.05).There was a significant positive correlation between MFV and PSV and serum miR-27a levels in patients with carotid artery stenosis(P<0.05).MFV,EDV,PSV,plaque eccentricity index,plaque enhancement degree and serum miR-27a level in patients with carotid artery stenosis were significantly positively correlated with carotid artery stenosis rate(P<0.05).The AUC of PSV,plaque enhancement degree and serum miR-27a level in predicting prognosis of patients with carotid artery stenosis were 0.764(95%CI:0.662-0.866),0.649(95%CI:0.519-0.779)and 0.832(95%CI:0.748-0.916),respectively.The AUC of PSV and plaque enhancement combined with serum miR-27a predicted the prognosis of patients with carotid artery stenosis was 0.895(95%CI:0.830-0.960).Conclusion Carotid ultrasound and high-resolution MRI parameters combined with serum miR-27a have a certain value in predicting the prognosis of patients with carotid artery stenosis after surgery.关键词
颈动脉狭窄/颈动脉超声/高分辨磁共振/miR-27a/预后Key words
Carotid artery stenosis/Carotid ultrasound/High-resolution MRI/miR-27a/Prognosis分类
医药卫生引用本文复制引用
杨静,张玲,李秀岩,周欣彤..颈动脉超声高分辨MRI联合血清miR-27a预测颈动脉支架植入术后抗血小板治疗患者预后的价值[J].中国实用神经疾病杂志,2024,27(1):48-53,6.基金项目
大庆市指导性科技计划项目(编号:zdy-2019-17) （编号:zdy-2019-17）
