中国实用神经疾病杂志2024，Vol.27Issue(1)：85-89,5.DOI:10.12083/SYSJ.230827
新生儿缺氧缺血性脑病血清miR-124与miR-126的表达及临床意义
Expression and clinical significance of serum miR-124 and miR-126 in neonatal hypoxic-ischemic encephalopathy
摘要
Abstract
Objective To investigate the expression and clinical significance of serum micro ribonucleic acid(miR)-124 and miR-126 in neonatal hypoxic-ischemic encephalopathy(HIE).Methods Totally 92 children with HIE admitted to the Affiliated Hospital of Xiangnan University from January 2019 to February 2023 were selected as the HIE group,and were divided into 44 cases in the mild group,27 cases in the moderate group and 21 cases in the severe group according to the severity of the disease,and 31 healthy newborns in the same period were selected as the control group.Spearman correlation was used to analyze the correlation between serum miR-124 and miR-126 expressions and S100B and NSE levels in children with HIE,and receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum miR-124 and miR-126 levels on neonatal HIE.Results Compared with the control group,serum miR-124 and miR-126 expressions were decreased and S100 calcium-binding protein B(S100B)and neuron-specific enolase(NSE)levels were increased in the HIE group(P＜0.05).Serum miR-124 and miR-126 expressions were decreased and S100B and NSE levels were increased in the mild,moderate and severe groups in that order(P＜0.05).Spearman correlation analysis showed that serum miR-124 and miR-126 expressions in children with HIE were negatively correlated with S100B and NSE levels(rs=—0.757,—0.781,—0.800,—0.785,all P＜0.001).ROC curve analysis showed that the area under the curve for serum miR-124 and miR-126 expression alone and in combination for the diagnosis of neonatal HIE was 0.872,0.882,and 0.946,respectively.Conclusion Serum miR-124 and miR-126 are lowly expressed in neonatal HIE and may be involved in the neonatal HIE process through neuronal cell injury,and the combined serum miR-124 and miR-126 expression is of high value in the diagnosis of neonatal HIE.关键词
新生儿缺氧缺血性脑病/微小核糖核酸-124/微小核糖核酸-126/S100钙结合蛋白B/神经元特异性烯醇化酶/诊断价值Key words
Neonatal hypoxic-ischemic encephalopathy/Micro ribonucleic acid-124/Micro ribonucleic acid-126/S100 calcium-binding protein B/Neuron-specific enolase/Diagnostic value分类
临床医学引用本文复制引用
王岳斌,刘珍凤,李利香,吴晓青,苏维..新生儿缺氧缺血性脑病血清miR-124与miR-126的表达及临床意义[J].中国实用神经疾病杂志,2024,27(1):85-89,5.基金项目
湖南省自然科学基金科卫联合基金项目(编号:2022JJ70041) （编号:2022JJ70041）
