河南中医2023，Vol.43Issue(12)：1839-1844,6.DOI:10.16367/j.issn.1003-5028.2023.12.0354
运动训练配合穴位埋线对缺血性脑卒中大鼠运动功能的影响
The Influence of Exercise Training Combined with Catgut Embedment in Acupoint on Motor Function of Rats with Ischemic Stroke
摘要
Abstract
Objective;To study the influence of exercise training combined with catgut embedment in acupoint on motor function of rats with ischemic stroke and to explore its mechanism.Methods:A total of 60 healthy male SPF-grade SD rats were randomly divided into the sham operation group,the model group,the group of catgut embedment in acupoint,the exercise training group and the combined group,with 12 rats in each group.Except the sham operation group,all the other groups prepared ischemic stroke rats models.After the modeling was completed,the intervention began:the group of catgut embedment in acupoint was given catgut embedment in acupoint,the exercise training group was given wheel training,and the combined group was given wheel training and catgut embedment in acupoint for 14 consecutive days.The sham operation group and the model group did not receive any intervention.On the 1st,7th and 14th day of the intervention,the neurological function of rats was scored respectively according to the Garcia score.The changes in the grasping ability and muscle strength of the left limb of rats were evaluated by the net screen test.The balance stability of rats was evaluated by the bal-ance beam test.The morphological changes in brain tissues of rats in each group were observed by HE staining.Results:Compared with the sham operation group,the neurological function score and net screen test score of the model rats were decreased,while the balance function score,arrival time of balance beam test and the number of false steps in the balance beam test were increased,with statistically significant differences(P＜0.05).Compared with the model group,on the 7th and 14th day,the neurological function score and net screen test score of the exercise training group,the group of catgut embedment in acupoint,and the combined group were increased,while the balance function score,arrival time of balance beam test and the number of false steps in the balance beam test were de-creased,and the effect of the combined group was significantly better than that of the exercise training group and the group of catgut em-bedment in acupoint,with statistically significant differences(P＜0.05).HE staining showed that the brain tissue of the model rats was disordered,with incomplete cell structure,vacuolar,and reduced number of neurons.The pathological damage of the combined group was the least.Conclusion:Exercise training combined with catgut embedment in acupoint can effectively reduce ischemic brain tissue injury of the patients,improve neurological function,and significantly improve their motor dysfunction after stroke.关键词
缺血性脑卒中/运动训练/穴位埋线/运动功能/大鼠Key words
ischemic stroke/exercise training/catgut embedment in acupoint/motor function/rat分类
中医学引用本文复制引用
郑苏,黄琴,胥婧,谢谨,张刚..运动训练配合穴位埋线对缺血性脑卒中大鼠运动功能的影响[J].河南中医,2023,43(12):1839-1844,6.基金项目
湖北省卫生健康委员会中医科研项目(ZY2021Q015) （ZY2021Q015）
太和医院院级项目(2021JJXM077,2019JJXM099,2016JJXM023) （2021JJXM077,2019JJXM099,2016JJXM023）
