湖南中医药大学学报2023，Vol.43Issue(12)：2305-2312,8.DOI:10.3969/j.issn.1674-070X.2023.12.024
基于ERAD-ERSIA稳态探讨健脾益肾法干预癌症恶病质骨骼肌萎缩
Method of strengthening the spleen and benefiting the kidney for intervening skeletal muscle atrophy in cancer cachexia based on ERAD-ERSIA homeostasis
摘要
Abstract
Cancer cachexia(CC)is a common fatal complication of advanced cancer,and modern medical nutritional support can only alleviate CC to a certain extent with poor efficacy on the whole.CC belongs to the category of"deficiency"in Chinese medicine with deficiency of the spleen and kidney as its main pathogenesis.For now,the method of strengthening the spleen and benefiting the kidney can effectively intervene CC,but its specific mechanism remains to be elucidated.It is believed that endoplasmic reticulum stress(ERS)is closely related to CC skeletal muscle atrophy.Furthermore,ER-associated degradation(ERAD)pathways can be activated under moderate ERS,which is conducive to the restoration of homeostasis and survival of muscle cells.However,if endoplasmic reticulum stress induced apoptosis(ERSIA)is activated under sustained or high intensity ERS,it will cause apoptosis of muscle cells and lead to skeletal muscle atrophy.This paper discusses the method of strengthening the spleen and benefiting the kidney for intervening CC skeletal muscle atrophy by ERAD-ERSIA homeostasis,providing ideas for the mechanism study on TCM method of strengthening the spleen and benefiting the kidney in improving CC.关键词
癌症/恶病质/内质网应激/内质网应激相关性降解/骨骼肌萎缩/健脾益肾Key words
cancer/cachexia/endoplasmic reticulum stress/ER-associated degradation/skeletal muscle atrophy/strength-ening the spleen and benefiting the kidney分类
中医学引用本文复制引用
王理槐,孙银辉,陈晟,刘正艺,胡宇翔,万多,田雪飞..基于ERAD-ERSIA稳态探讨健脾益肾法干预癌症恶病质骨骼肌萎缩[J].湖南中医药大学学报,2023,43(12):2305-2312,8.基金项目
湖南省自然科学基金项目(2021JJ30525) （2021JJ30525）
湖南中医药大学一流学科开放基金项目(2019ZXYJH03) （2019ZXYJH03）
湖南省科学技术厅湖南省中医肿瘤临床研究中心平台项目(2021SK4023). （2021SK4023）
