四川大学学报（医学版）2023，Vol.54Issue(6)：1080-1084,5.DOI:10.12182/20231160506
组蛋白修饰在急性肾损伤向慢性肾脏病转化中的作用
Role of Histone Modifications in Acute Kidney Injury Progressing to Chronic Kidney Disease
摘要
Abstract
Acute kidney injury(AKI),a clinical syndrome caused by various factors,is characterized by a rapid decline in kidney function in a short period of time.AKI affects the short-term prognosis of patients and may also induce chronic kidney disease(CKD).However,the current treatment options for AKI mainly focus on symptom management.Specific therapeutic measures available for the prevention of transition from AKI to CKD are very limited in number.Histones are basic proteins that intricately bind the DNA in chromosomes.After translation,histones undergo various modifications on their amino-terminal tails,such as methylation,acetylation,phosphorylation,ubiquitination,and lactylation,collectively forming the"histone code",which affects the expression of genes mainly by regulating the elastic structure of chromatin or recruiting specific proteins.Extensive research conducted in recent years on histone post-translational modifications(PTMs)has also sparked continuous interest in their association with the AKI-to-CKD transition.Therefore,this paper highlights the significant role of PTMs in the process of AKI developing and progressing to CKD,with a view to finding new approaches to preventing the progression of AKI to CKD.关键词
组蛋白修饰/急性肾损伤/慢性肾脏病/甲基化/乙酰化/综述Key words
Histone modification/Acute kidney injury/Chronic kidney disease/Methylation/Acetylation/Review引用本文复制引用
郭淑娴,张择阳,赵晋,袁进国,孙世仁..组蛋白修饰在急性肾损伤向慢性肾脏病转化中的作用[J].四川大学学报（医学版）,2023,54(6):1080-1084,5.基金项目
国家自然科学基金(No.82170722)和空军军医大学博士后蓝剑基金(No.lj20220102)的资助 （No.82170722）
