四川大学学报（医学版）2023，Vol.54Issue(6)：1085-1090,6.DOI:10.12182/20231160107
肾小管上皮细胞应激性衰老在糖尿病肾病中的研究进展
Research Progress in Stress-Induced Senescence of Renal Tubular Cells in Diabetic Nephropathy
摘要
Abstract
Diabetic nephropathy(DN)is the leading cause of end-stage renal disease.Renal tubulointerstitial injury is an important pathophysiological basis that contributes to the progression of DN to end-stage renal disease.Stress-induced senescence of renal tubular epithelial cells(RTECs)forms a key link that causes tubulointerstitial injury.In recent years,it has been reported that organelles,such as endoplasmic reticulum,mitochondria,and lysosomes,in RTECs are damaged to varying degrees in DN,and that their functional imbalance may lead to stress-induced senescence of RTECs,thereby causing sustained cellular and tissue-organ damage,which in turn promotes the progression of the disease.However,the core mechanism underlying changes in the senescence microenvironment caused by stress-induced senescence of RTECs in DN is still not understood.In addition,the mechanism by which organelles lose homeostasis also needs to be further investigated.Herein,we described the specific pathophysiological mechanisms of renal tubular injury,stress-induced senescence of RTECs,and their association with organelles in the context of DN in order to provide reference for the next-step research,as well as the development of new therapeutic strategies.关键词
肾小管上皮细胞/应激性衰老/糖尿病肾病/综述Key words
Renal tubular epithelial cells/Stress-induced senescence/Diabetic nephrology/Review引用本文复制引用
易香伶,何娅妮,陈客宏..肾小管上皮细胞应激性衰老在糖尿病肾病中的研究进展[J].四川大学学报（医学版）,2023,54(6):1085-1090,6.基金项目
国家自然科学基金(No.82270768)、重庆市课题(No.CSTB2023NSCQ-MSX0584)和重点实验室开放课题(No.2022YSZX-JCX0007CSTB)资助 （No.82270768）
