四川大学学报（医学版）2023，Vol.54Issue(6)：1201-1207,7.DOI:10.12182/20231360303
精神分裂症患者服药依从性与不同类型危险行为的关联研究
Association Between Medication Compliance and Various Risky Behaviors in Patients With Schizophrenia
摘要
Abstract
Objective To investigate the status of medication adherence and various types of risky behaviors of schizophrenia patients in a certain area of western China and to explore accordingly the correlation between the two.Methods A total of 292 667 patients with schizophrenia were enrolled in a follow-up survey between 2006 and 2018.In addition,based on the outcome-wide analysis strategy,a multivariate Cox proportional risk regression model was used to estimate and compare the impact of medication adherence on different types of risky behaviors in schizophrenia patients.Results In this 13-year prospective cohort,65 175 patients(31.4％)showed good medication adherence,while 142 394 patients(68.6％)showed poor medication adherence.The incidence rates of various risky behaviors during the follow-up period were as follows,minor nuisances,12.25％,violation of the Law of the People's Republic of China on Penalties for Administration of Public Security(APS law),3.82％,violation of criminal law,0.94％,suicide completed,0.28％,self-harm,1.42％,and attempted suicide,0.82％.Schizophrenia patients who had poor medication adherence had higher risks of committing violence against others and self-inflicted injury compared to patients with good medication adherence did,with the associated effects being minor nuisances(hazard ratio[HR]=1.31,95％confidence interval[CI]:1.27-1.35),violation of APS law(HR=1.47,95％CI:1.38-1.56),violation of criminal law(HR=1.17,95％CI:1.05-1.31),and self-harm(HR=1.43,95％CI:1.32-1.56),respectively,while the risk of suicide completed is lower in schizophrenia patients with poor medication adherence than that in patients with good medication adherence(HR=0.56,95％CI:0.47-0.66).There was no statistically significant association between attempted suicide and medication adherence.Conclusion There are variations in the direction and strength of the association between medication adherence and different types of risky behaviors and further research is needed to elucidate the mechanisms of the association.关键词
精神分裂症/服药依从性/危险行为/Outcome-Wide分析Key words
Schizophrenia/Medication compliance/Risky behavior/Outcome-wide analysis引用本文复制引用
魏泸懿,刘祥,刘元元,杨先梅,范箬馨,王丹,刘军,何昌九,李杨,左传隆,周涵闻..精神分裂症患者服药依从性与不同类型危险行为的关联研究[J].四川大学学报（医学版）,2023,54(6):1201-1207,7.基金项目
国家自然科学基金(No.81903414)和四川省科普培训项目(No.2021JDKP0034)资助 （No.81903414）
