解放军医学杂志2023，Vol.48Issue(12)：1427-1432,6.DOI:10.11855/j.issn.0577-7402.2162.2023.0523
达格列净对老年急性心肌梗死后心力衰竭患者心功能及MACE的影响
Effect of dapagliflozin on cardiac function and MACE in elderly patients with heart failure after acute myocardial infarction
摘要
Abstract
Objective To investigate the effect of dapagliflozin on cardiac function and major adverse cardiac events(MACE)in elderly patients with heart failure after acute myocardial infarction.Methods The clinical data of 59 elderly patients with heart failure after acute myocardial infarction,treated in Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology from May 2021 to February 2022,were collected and retrospectively analyzed.The objects were divided into control group(n=29)and dapagliflozin group(n=30)according to whether they took dapagliflozin during routine treatment.The cardiac function indexes[left vetricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]and the level of N-terminal pro-brain natriuretic peptide(NT-proBNP);as well as clinical total effective rate,Killip grading and MACE occurrence were detected and compared at discharge and within 6 months after discharge.Results At discharge and within 6 months'treatment,the levels of LVEF increased(P<0.05),and of LVEDD,LVESD and NT-proBNP decreased(P<0.05)in the two groups than those before treatment.The level of LVEF in the dapagliflozin group was higher(P<0.05),and the levels of LVEDD,LVESD and NT-proBNP were lower in dapagliflozin group(P<0.05)than those in control group.There was no statistical difference in the clinical total effective rate between the two groups(86.7%vs.65.5%,P>0.05)at discharge;The clinical total effective rate of dapagliflozin group was 93.3%,which was higher than control group of 62.1%within 6 months'treatment(P<0.05).Before treatment,at discharge and within 6 months'treatment,there was no statistical difference in the Killip classification between the two groups(P≥0.05).The incidence of MACE in dapagliflozin group was lower than that in control group within 6 months'treatment(P<0.05).Conclusion Compared with conventional anti heart failure therapy,combined with dapagliflozin can improve the cardiac function and prognosis,reduce the incidence of MACE of patients with heart failure after acute myocardial infarction.关键词
急性心肌梗死/心力衰竭/达格列净/心功能/主要心血管不良事件Key words
acute myocardial infarction/heart failure/dapagliflozin/cardiac function/major adverse cardiovascular events分类
医药卫生引用本文复制引用
刘侃玲,张瑶..达格列净对老年急性心肌梗死后心力衰竭患者心功能及MACE的影响[J].解放军医学杂志,2023,48(12):1427-1432,6.基金项目
This work was supported by the Natural Science Foundation General Program in Hubei Province(2021CFB337) 湖北省自然科学基金一般面上项目(2021CFB337) （2021CFB337）
