解放军医学杂志2023，Vol.48Issue(12)：1467-1472,6.DOI:10.11855/j.issn.0577-7402.1106.2023.0227
干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展
Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency
摘要
Abstract
Premature ovarian insufficient(POI)is one of the important causes of infertility in woman of reproductive age.At present,the clinical treatment of POI is limited and the therapeutic effect is not ideal.Extracellular vesicles derived from stem cells have attracted the attention of many researchers at home and abroad as a new cell-free therapy.Many animal experiment study shows that a variety of extracellular vesicles from stem cells carry microRNAs,lncRNAs,lipids,proteins,and other bioactive substances,improve ovarian function,affect granulosa cell proliferation and apoptosis,promote ovarian angiogenesis,and reduce oxidative stress response,thus playing a therapeutic role on POI.This article will review the mechanisms of extracellular vesicles in treatment of POI,and provide evidence for the application of extracellular vesicles in clinical treatment of POI.关键词
早发性卵巢功能不全/细胞外囊泡/外泌体/干细胞源性Key words
premature ovarian insufficient/extracellular vesicles/exosomes/stem cell-derived分类
临床医学引用本文复制引用
曾文卓,黄欣怡,徐数理,孙晓峰..干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展[J].解放军医学杂志,2023,48(12):1467-1472,6.基金项目
This work was supported by the National Natural Science Foundation of China(81774362,81303004),the Natural Science Foundation of Hunan Province(2018JJ2290),and the Natural Science Foundation of Changsha City(kq2208187) 国家自然科学基金(81774362,81303004) （81774362,81303004）
湖南省自然科学基金(2018JJ2290) （2018JJ2290）
长沙市自然科学基金(kq2208187) （kq2208187）
