荆楚理工学院学报2023，Vol.38Issue(6)：1-5,5.
钛酸钾晶须改性PMMA的生物相容性研究
Study on the Biocompatibility of PMMA Modified by Potassium Titanate Whisker
摘要
Abstract
Objective:To evaluate the biocompatibility of PMMA modified by potassium titanate whisker.Methods:Potassium titanate whisker modified PMMA material was prepared by grinding the surface of potassium titanate whisker with silane coupling agent and mixing it with PMMA powder in a certain proportion.PMMA and modified material were soaked in the medium to prepare the leaching liquor as the experimental group,and the original medium as the negative control group.L929 cells were co-cultured with the leaching liquor of each group.The cell proliferation was detected by MTT assay and the oxidative damage was evaluated by reactive oxygen species(ROS)assay,to evaluate the biocompatibility of PMMA modified by potassium titanate whisker.Results:The cell proliferation rate of PMMA modified by potassium titanate whisker was 85.3%,and the cytotoxicity was grade 1,which was considered as non-cytotoxicity according to the ISO standard.The amount of ROS in PMMA modified with potassium titanate whisker was significantly higher than that in the negative control group(P<0.001),but there was no significant difference between the two experimental groups.Conclusion:PMMA modified by potassium titanate whisker have acceptable Biocompatibility.关键词
钛酸钾晶须/聚甲基丙烯酸甲酯/生物相容性Key words
potassium titanate whisker/PMMA/Biocompatibility分类
医药卫生引用本文复制引用
黄天意,高海,夏鸿,邱滢..钛酸钾晶须改性PMMA的生物相容性研究[J].荆楚理工学院学报,2023,38(6):1-5,5.基金项目
荆楚理工学院科研项目(YB202204 （）
ZD202210 （）
HX20220079) （）
大学生创新创业计划项目(KC2022045) （KC2022045）
