解剖学杂志2023，Vol.46Issue(5)：422-427,6.DOI:10.3969/j.issn.1001-1633.2023.05.011
线粒体质量控制系统在中枢神经系统疾病中的研究进展
Research progress of mitochondrial quality control system in central nervous system diseases
摘要
Abstract
Mitochondrial quality control(mitoQC)refers to the dynamic coordinated cycling of mitochondria through uninterrupted biogenesis,dynamics(fission/fusion),autophagy,mitocytosis and translocation.MitoQC is becoming the core regulator of central nervous system(CNS)homeostasis.As the"powerhouse"of neurons,mitochondria is one of the most important organelles for neuron metabolism and homeostasis.Maintaining the activity and functional integrity of mitochondria is very important to the health of neurons.It is well known that neuronal death and functional defects are important causes of neurological dysfunction in patients with CNS diseases.This article focused on the internal relationship between mitoQC disorder and CNS diseases.The study was aimed to briefly review the research mechanisms of maintaining and/or restoring neuronal mitochondrial homeostasis and its related cellular life processes.关键词
线粒体质量控制/脑/脑卒中/创伤/退行性疾病Key words
mitochondria quality control/brain/stroke/trauma/degenerative disease引用本文复制引用
韩灵灵,高俊玲..线粒体质量控制系统在中枢神经系统疾病中的研究进展[J].解剖学杂志,2023,46(5):422-427,6.基金项目
河北省自然科学基金(H2019105137) （H2019105137）
