解剖学杂志2023，Vol.46Issue(5)：428-431,4.DOI:10.3969/j.issn.1001-1633.2023.05.012
线粒体自噬在器官纤维化疾病中作用的研究进展
Research progress on the role of mitophagy in organ fibrotic diseases
摘要
Abstract
Mitochondrial autophagy is a specific autophagy phenomenon that selectively degrades damaged or redundant mitochondria in cells,enabling cells to maintain the stability of mitochondrial quantity and quality during stress damage,thereby maintaining the normal phenotype and function of cells.Its molecular mechanism is relatively complex,mainly involving PINK1/Parkin pathway,NIX and BNIP3,FUNDC1 and so on.The abnormality of mitophagy is closely related to a variety of diseases,and the role of molecular mechanisms regulating mitophagy at different stages in the development of diseases has been paid attention to.The research progress of mitophagy in fibrotic lesions of various organs in recent years is summarized as follows.关键词
器官纤维化/细胞自噬/线粒体自噬Key words
organ fibrosis/autophagy/mitophagy引用本文复制引用
高晓阳,金蓉,赵晓璐,张春艳,颜羽昕,马月宏..线粒体自噬在器官纤维化疾病中作用的研究进展[J].解剖学杂志,2023,46(5):428-431,4.基金项目
国家自然科学基金(81960759,81560706) （81960759,81560706）
内蒙古自治区自然科学基金(2019MS08010,2014MS0841) （2019MS08010,2014MS0841）
内蒙古自治区草原英才培养计划(No.内人社办发[2016]348号) （No.内人社办发[2016]348号）
内蒙古医科大学致远人才项目(2020-11) （2020-11）
内蒙古人才开发基金(2022年-个人项目22056) （2022年-个人项目22056）
内蒙古医科大学蒙药抗肝纤维化作用研究科技创新团队(2022-01) （2022-01）
内蒙古医科大学重点项目(YKD2022ZD019) （YKD2022ZD019）
