实用心电学杂志2023，Vol.32Issue(6)：389-394,6.DOI:10.13308/j.issn.2095-9354.2023.06.002
伊伐布雷定对慢性心力衰竭患者QT间期和心率的影响
Effect of ivabradine on QT interval and heart rate in patients with chronic heart failure
邸成业 1王群 1吴岩熹 1李龙雨 1张岩 1林文华1
作者信息
- 1. 300457 天津,泰达国际心血管病医院心内科
- 折叠
摘要
Abstract
Objective To explore the effect of ivabradine on QT interval and sinus rhythm in patients with chronic heart failure(HF).Methods A total of 179 patients with chronic HF were selected as the research subjects.They underwent 12-lead synchronous ambulatory electrocardiography(AECG)examination,and re-examination of AECG 30-45 days after oral administration of ivabradine.The changes of QT interval and heart rate before and after medication were compared.Results A total of 143 patients complete clinical follow-up and are enrolled in this study.After oral administration of ivabradine,the maximum QT interval[(467.9±62.6)ms vs.(473.6±63.4)ms],the maximum QTc[(489.3±56.0)ms vs.(496.6±55.4)ms],the average QT interval[(390.5±41.1)ms vs.(398.6±43.7)ms],the average QTc[(417.2±31.4)ms vs.(414.4±36.9)ms],and the minimum QTc[(377.5±36.0)ms vs.(361.3±37.0)ms]of all the 143 patients are significantly different from those before medication(P＜0.01).The minimum QT interval[(348.3±42.8)ms vs.(349.6±38.9)ms]does not vary significantly before and after medication(P＞0.05).The differences of the minimum heart rate[(50.3±8.6)times per minute vs.(47.7±7.8)times per minute],the average heart rate[(69.9±11.7)times per minute vs.(64.9±10.6)times per minute],and the maximum heart rate[(116.6±23.1)times per minute vs.(109.0±20.1)times per minute]are all statistically significant before and after medication(P＜0.01).During the follow-up period,there is no incidence of ventricular arrhythmia or sudden death.Conclusion Ivabradine could significantly shorten the maximum QT interval/QTc and the average QT interval,and slow down heart rate.Its clinical application is safe and effective.关键词
心力衰竭/伊伐布雷定/QT间期/QTc/动态心电图Key words
heart failure/ivabradine/QT interval/QTc/ambulatory electrocardiography分类
医药卫生引用本文复制引用
邸成业,王群,吴岩熹,李龙雨,张岩,林文华..伊伐布雷定对慢性心力衰竭患者QT间期和心率的影响[J].实用心电学杂志,2023,32(6):389-394,6.
