实用心电学杂志2023，Vol.32Issue(6)：411-415,5.DOI:10.13308/j.issn.2095-9354.2023.06.006
冠心病合并2型糖尿病患者小而密低密度脂蛋白与冠状动脉狭窄的相关性
Correlation between small and dense low-density lipoprotein and coronary stenosis in patients with coronary heart disease complicating type 2 diabetes
摘要
Abstract
Objective To investigate the relationship between small and dense low-density lipoprotein(sd-LDL)and coronary stenosis in patients with coronary heart disease(CHD)complicating type 2 diabetes.Methods We collected the clinical data and testing results of 326 CHD patients with type 2 diabetes.Quantitative evaluation of coronary artery were performed according to coronary angiography results and by using Gensini Scoring.According to the average Gensini Score and the type of disease respectively,all the patients were grouped and made statistical analysis.Results There is no statistically significant difference in sex,history of hypertension or LDL between groups while the differences of age,glycosylated hemoglobin and sd-LDL are statistically significant(P＜0.05).The index of sd-LDL(OR=1.129,95%CI 1.075-1.221,P＜0.01)is correlated with the severity of coronary artery lesion.Its sensitivity and specificity are separately 57%and 88%in predicting the degree of coronary stenosis.Conclusion Among patients with CHD and type 2 diabetes,sd-LDL is an independent risk factor for the severity of coronary artery lesion.关键词
小而密低密度脂蛋白/Gensini评分/冠状动脉狭窄/糖尿病/冠心病Key words
small and dense low-density lipoprotein/Gensini Scoring/coronary stenosis/diabetes mellitus/coronary heart disease分类
医药卫生引用本文复制引用
姜珊,刘彤彤,栾春雨,张鹏..冠心病合并2型糖尿病患者小而密低密度脂蛋白与冠状动脉狭窄的相关性[J].实用心电学杂志,2023,32(6):411-415,5.基金项目
山东第一医科大学(山东省医学科学院)青年科学基金培育资助计划项目(202201-102) （山东省医学科学院）
山东省学校卫生协会课题项目(SDW2022179,SDW2022143) （SDW2022179,SDW2022143）
