检验医学与临床2023，Vol.20Issue(24)：3585-3588,3593,5.DOI:10.3969/j.issn.1672-9455.2023.24.001
卡格列净联合阿魏酸哌嗪片对糖尿病肾病患者肾功能、血糖及血清胰岛素样生长因子1影响的随机对照研究
A randomized controlled study on effect of canagliflozin combined with piperazine ferulate tablets on renal function,blood glucose and serum insulin-like growth factor 1 in patient with diabetic nephropathy
摘要
Abstract
Objective To investigate the application effect of canagliflozin combined with piperazine feru-late tablets in the treatment of diabetic nephropathy(DN).Methods Eighty-two patients with DN conforming to the study condition admitted and treated in Xi'an International Medical Center Hospital and Shaanxi Pro-vincial Rehabilitation Hospital from June 2021 to December 2022 were randomly selected as the study subjects and divided into the control group and observation group by the random number table method to conduct the single-blind study,41 cases in each group.All patients were treated with the routine hypoglycemic therapy,on this basis the control group was given piperazine ferulate tablet,while the observation group was treated with canagliflozin combined with piperazine ferulate tablets.The clinical effects were evaluated and compared be-tween the two groups,meanwhile the changes of blood glucose,kidney function,serum inflammatory factor and insulin-like growth factor 1(IGF-1)levels were observed.Results After treatment,the total effective rate in the observation group was 90.24％,which was higher than 73.17％in the control group,and the differ-ence was statistically significant(P＜0.05);after treatment,the levels of fasting blood glucose,2 h postprandi-al blood glucose,glycosylated hemoglobin,blood creatinine,blood urea nitrogen,24 h urine protein quantifica-tion,interleukin 6,tumor necrosis factor a and IGF-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Canagliflozin com-bined with piperazine ferulate tablets in treating DN can further control the patients'blood glucose and IGF-1 levels,improve the renal function and inflammation status,then subsequently enhance the clinical effects.关键词
糖尿病肾病/卡格列净/阿魏酸哌嗪片/胰岛素样生长因子1/血糖/肾功能指标Key words
diabetic nephropathy/canagliflozin/piperazine ferulate tablets/insulin-like growth fac-tor 1/blood glucose/renal function index分类
医药卫生引用本文复制引用
张婷,李艳,马辽,徐倩倩,赵秋红,张萌..卡格列净联合阿魏酸哌嗪片对糖尿病肾病患者肾功能、血糖及血清胰岛素样生长因子1影响的随机对照研究[J].检验医学与临床,2023,20(24):3585-3588,3593,5.基金项目
陕西省重点研发项目(2019SF-181). （2019SF-181）
