检验医学与临床2023，Vol.20Issue(24)：3589-3593,5.DOI:10.3969/j.issn.1672-9455.2023.24.002
高危型人乳头瘤病毒感染与泌尿生殖道支原体感染的关系分析
Analysis on relationship between high-risk human papillomavirus infection and urogenital tract mycoplasma infection
摘要
Abstract
Objective To analyze the relationship between high risk human papilloma virus(HR-HPV)in-fection and urogenital tract mycoplasma infection to provide reference for clinical diagnosis and treatment.Methods The HR-HPV detection results,urogenital tract mycoplasma detection results and drug sensitivity results in 9 662 female patients with suspected urogenital tract infection admitted to Puning Municipal People's Hospital from May 2021 to December 2022 were retrospectively analyzed.Results Among 9 662 pa-tients,the mycoplasma infection rate in the patients with HR-HPV positive was 62.8％,which was signifi-cantly higher than 41.4％in the patients with HR-HPV negative,and the difference was statistically signifi-cant(P＜0.05).The mixed infection type of HR-HPV and mycoplasma was dominated by HR-HPV+Uu.In the drug sensitivity test,when HR-HPV and mycoplasma mixed infection,the sensitivity rate of mycoplasma to doxycycline,minocycline and josamycin was the highest(≥96.0％),the resistance to quinolones(ofloxacin,norfloxacin)was generally high(resistance rate ≥85.4％).There was no statistically significant difference in the resistance rate between HR-HPV positive patients and HR-HPV negative patients among the 12 antimi-crobial agents in individual Mh infections and Uu+Mh mixed infections(P＞0.05).In separate Uu infec-tions,the resistance rates of HR-HPV positive patients to second-generation macrolide drugs(roxithromycin,clarithromycin,azithromycin)and quinolones(ofloxacin,norfloxacin)were significantly higher than those of HR-HPV negative patients,and the differences were statistically significant(P＜0.05).Conclusion The pa-tients with HR-HPV infection have the relatively high probability of complicating mycoplasma urogenital tract infection.HR-HPV infection could increase the resistance of Uu to roxithromycin,clarithromycin,az-ithromycin,norfloxacin and norfloxacin.Therefore,in clinical selection of drugs for the treatment of HR-HPV and Uu mixed infection,the use of such drugs should be avoided as far as possible,and the antibiotics such as doxycycline,minocycline and josamycin should be selected.关键词
高危型人乳头瘤病毒/解脲支原体/人型支原体/药敏试验Key words
high-risk human papilloma virus/ureaplasma urealyticum/mycoplasma hominis/drug sensitivity test分类
医药卫生引用本文复制引用
陈海城,谢平霖,方炳雄,余彩瑶,庄蓓丽..高危型人乳头瘤病毒感染与泌尿生殖道支原体感染的关系分析[J].检验医学与临床,2023,20(24):3589-3593,5.基金项目
广东省揭阳市科技计划项目(sxm036). （sxm036）
