检验医学与临床2023，Vol.20Issue(24)：3603-3606,4.DOI:10.3969/j.issn.1672-9455.2023.24.005
围生期孕妇感染B族链球菌血清型与不良妊娠结局的关系
Relationship between serotypes of group B Streptococcus infection in perinatal pregnant women and adverse pregnancy outcomes
摘要
Abstract
Objective To understand the infection rate of group B Streptococcus(GBS)in the reproductive tract of perinatal pregnant women,and to explore the GBS infection status and the relationship between its se-rotypes and adverse pregnancy outcomes.Methods A total of 1 294 perinatal pregnant women who estab-lished the card for conducting the prenatal examination and delivered in this hospital from July 2019 to Decem-ber 2020 were selected as the research subjects.Their vaginal secretions conducted the GBS bacterial culture at admission,and the subjects with GBS culture positive conducted the GBS serotyping.The pregnant women with GBS positive were included in the positive group,and the GBS negative pregnant women were randomly extracted with 1∶3 ratio as the negative group.The adverse pregnancy outcomes were compared between the two groups,and the distribution situation of GBS infection serotypes in pregnant women with adverse preg-nancy outcomes was analyzed.Results There were 75 cases of GBS culture positive.The positive group had 75 pregnant women and negative group had 225 pregnant women.The infection rate of GBS in the reproduc-tive tract of perinatal pregnant women was 5.80％(75/1 294).The incidence rates of premature rupture of membranes and postpartum hemorrhage in pregnant women of the positive group were 30.67％and 6.67％,respectively,which were higher than those in the negative group(16.89％,1.33％),and the differences were statistically significant(P＜0.05);There was no statistically significant difference in the incidence rates of premature birth,fetal distress and chorioamnionitis between the two groups(P＞0.05).Among 23 pregnant women with premature rupture of membranes in the positive group,the proportion of type Ⅲ GBS infection was the highest,accounting for 60.87％,followed by type Ⅰ b(26.09％)and type Ⅰ a(13.04％);the propor-tion of type Ⅰ b GBS infection among 5 pregnant women with postpartum hemorrhage was the highest,ac-counting for 60.00％,which of both types Ⅰ a and Ⅲ accounted for 20.00％.The incidence rates of adverse pregnancy outcomes among the pregnant women infected with type Ⅰ b and type Ⅲ GBS in the positive group were 60.00％(12/20)and 54.84％(17/31),respectively,which were higher than 25.00％(6/24)of type Ⅰa,and the differences were statistically significant(P＜0.05).Conclusion GBS infection increases the inci-dence rate of adverse pregnancy outcomes such as premature rupture of membranes and postpartum hemor-rhage in perinatal pregnant women.The pregnant women infected with type Ⅲ and Ⅰ b GBS have a higher in-cidence rate of adverse pregnancy outcomes.Therefore,it is necessary to strengthen the health education for pregnant women in clinical practice to prevent GBS infection and pay attention to screening and timely inter-vention of GBS and its serotypes in the reproductive tract of perinatal pregnant women to improve their preg-nancy outcomes.关键词
围生期/B族链球菌/感染/血清型/不良妊娠结局Key words
perinatal period/group B streptococcus/infection/serotype/pregnancy outcome分类
医药卫生引用本文复制引用
贾丽娜,佘欣..围生期孕妇感染B族链球菌血清型与不良妊娠结局的关系[J].检验医学与临床,2023,20(24):3603-3606,4.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190597). （Z20190597）
