检验医学与临床2023，Vol.20Issue(24)：3607-3610,4.DOI:10.3969/j.issn.1672-9455.2023.24.006
益肾健骨汤联合血液透析滤过治疗慢性肾脏病矿物质和骨异常的临床研究
Clinical study on Yishenjiangu Decoction combined with hemodialysis filtration on chronic kidney disease with mineral and bone abnormalities
摘要
Abstract
Objective To study the clinical efficacy of Yishenjiangu Decoction combined with hemodialysis filtration in the treatment of chronic kidney disease with mineral and bone abnormalities(CKD-MBD).Meth-ods According to the random number table method,80 CKD-MBD patients admitted to the hospital from A-pril 2021 to April 2022 were divided into control group and observation group,40 patients in each group.The control group was given the hemodialysis treatment,and the observation group was given Yishenjiangu Decoc-tion combined with the hemodialysis filtration treatment,both groups were treated for 3 months.The mineral and bone metabolism indexes,clinical efficacy and quality of life were compared between the two groups.Re-sults Compared with before treatment,the levels of blood phosphorus,whole parathyroid hormone(iPTH)and alkaline phosphatase(ALP)after treatment in the two groups were decreased(P＜0.05),while the levels of blood calcium and 25-hydroxyvitamin D[25(OH)D]were increased(P＜0.05);moreover ater treatment,the levels of blood phosphorus,iPTH and ALP in the observation group were lower than those in the control group(P＜0.05),while the levels of blood calcium and 25(OH)D were higher than those in the control group(P＜0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).Compared with before treatment,the SF-36 scores of the two groups after treatment were improved significantly(P＜0.05),and the observation group was higher compared to the control group(P＜0.05).Conclusion Yishenjiangu Decoction combined with hemodialysis filtration is effective in the treatment of the patients with CKD-MBD.It can regulate the mineral and bone metabolism indexes,improve the condition of bone and joint pain and skin itching and improve the quality of life.关键词
慢性肾脏病矿物质和骨异常/益肾健骨汤/血液透析滤过/骨代谢Key words
mineral and bone abnormalities in chronic renal disease/Yishenjiangu Decoction/hemodi-alysis filtration/bone metabolism index分类
医药卫生引用本文复制引用
胡春安,姚洁,李鑫..益肾健骨汤联合血液透析滤过治疗慢性肾脏病矿物质和骨异常的临床研究[J].检验医学与临床,2023,20(24):3607-3610,4.基金项目
江西省中医药管理局科技计划项目(2022B018). （2022B018）
