检验医学与临床2023，Vol.20Issue(24)：3611-3614,3618,5.DOI:10.3969/j.issn.1672-9455.2023.24.007
血清铁蛋白、锌、维生素D在抽动障碍儿童中的水平及意义
Levels and significance of serum ferritin,zinc and vitamin D in children with tic disorders
摘要
Abstract
Objective To investigate the relationship between serum ferritin,zinc and vitamin D with tic disorder(TD)in children.Methods A total of 161 children diagnosed with TD in a pediatric outpatient de-partment of our hospital from October 2020 to October 2022 were randomly selected as TD group,and 178 healthy children who underwent physical examination in the pediatric health outpatient department during the same period were selected as the healthy control group.The levels of serum ferritin,zinc and vitamin D were compared between the two groups.The levels of serum ferritin,zinc and vitamin D in TD children with differ-ent sex,disease course and severity were analyzed.Results The serum ferritin and zinc levels in the TD group were significantly lower than those in the healthy control group,and the differences were statistically signifi-cant(P＜0.05).The TD group showed insufficient serum 25 hydroxyvitamin D[25(O)H)D],and the serum 25(OH)D levels in the TD group was lower than that in the healthy control group,but the difference was not statistically significant(P＞0.05).There was no statistical difference in the serum ferritin,zinc and vitamin D levels between different genders of TD children(P＞0.05).There were significant differences in the ferritin,zinc and 25(OH)D levels between the TD children with disease course ≤12 months and the children with dis-ease course＞12 months(P＜0.05).The serum ferritin,zinc and 25(OH)D levels had statistical differences between the children with moderate and severe TD and the children with mild TD(P＜0.05).The incidence rate of insufficient 25(OH)D levels in the TD group was 29.81％,which was higher than 13.48％in the healthy control group,and the difference was statistically significant(P＜0.05).In the TD group,the inci-dence rate of insufficient 25(OH)D levels in males was 38.59％,which was higher than 8.51％in females,and the difference was statistically significant(P＜0.05).In the TD group,the incidence rate of insufficient 25(OH)D levels in TD children with a disease course of＞12 months was 41.18％,which was higher than 24.54％in TD children with a disease course of ≤ 12 months,and the difference was statistically significant(P＜0.05).Conclusion The serum ferritin and zinc levels in the children with TD are decreased;the insuffi-ciency of vitamin D increases the possibility of children suffering from TD.The longer the course of TD,the more obvious the degree of vitamin D deficiency.Detecting serum ferritin,zinc and vitamin D may have an im-portant significance for the earlier intervention and treatment of children with TD.关键词
抽动障碍/铁/锌/维生素D/儿童Key words
tic disorder/iron/zinc/vitamin D/children分类
医药卫生引用本文复制引用
罗明薇,肖红,饶敏,李娟,赵杨..血清铁蛋白、锌、维生素D在抽动障碍儿童中的水平及意义[J].检验医学与临床,2023,20(24):3611-3614,3618,5.基金项目
四川省攀枝花市科技局科研项目(2021ZD-S-18). （2021ZD-S-18）
