检验医学与临床2023，Vol.20Issue(24)：3627-3631,5.DOI:10.3969/j.issn.1672-9455.2023.24.011
重组人表皮生长因子凝胶辅助CO2点阵激光修复面部凹陷性痤疮瘢痕的效果分析
Analysis on repairing effect of rhEGF gel assisted CO2 dot matrix laser for repairing facial pitting acne scar
摘要
Abstract
Objective To observe the effect of recombinant human epidermal growth factor(rhEGF)gel assisted CO2 dot matrix laser in repairing facial pitting acne scar.Methods A total of 86 patients with pitting acne scars who visited the hospital from October 2019 to June 2021 were divided into the control group and observation group by using the random number table method,43 cases in each group.According to the falling off and exclusion criteria,41 cases were finally included in the control group and 42 cases in the observation group.Both groups were treated with CO2 dot matrix laser.After the laser treatment,the control group was coated with normal saline and the observation group was coated with rhEGF gel twice a day for 1 week,for continuous 1 week;laser treatment once per 2 months for 3 consecutive 3 times.The treatment effect,scar im-provement[Vancouver Scar Scale(VSS)score],skin moisture content,postoperative erythematous duration,eschar removal time,Self-rating Anxiety Scale(SAS)score,and Acne-specific quality of life Questionnaire(QoL-Acne)score and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 92.86％,which was higher than 85.37％in the control group,but the difference was not statistically significant(P＞0.05).After treatment,the scar VSS score in the observation group was significantly lower than that in the control group(P＜0.05).The skin water content at 1 week af-ter treatment in the observation group was significantly higher than that in the control group,the time of ery-thema duration and scab removal time were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the SAS score in the observation group was significantly lower than that in the control group(P＜0.05),and the emotional function,self-perception and social function scores in the observation group were significantly higher than those in the control group(P＜0.05).There was no statistical difference in the occurrence rate of adverse reactions between 2 groups(P＞0.05).Conclusion After CO2 dot matrix laser treatment,the rhEGF smear has a definite repair effect on facial pitting acne scars,which is conducive to effectively reduce skin damage,improve the facial skin quality,relieve anxiety and improve the life quality with high safety.关键词
痤疮瘢痕/CO2点阵激光/人表皮生长因子/修复效果Key words
acne scars/CO2 dot matrix laser/human epidermal growth factor/repair effect分类
医药卫生引用本文复制引用
赵丽靓,赵举辉..重组人表皮生长因子凝胶辅助CO2点阵激光修复面部凹陷性痤疮瘢痕的效果分析[J].检验医学与临床,2023,20(24):3627-3631,5.基金项目
陕西省汉中市中心医院院级科研基金中标项目(YK2214). （YK2214）
