Abstract
Objective To study the relationship between the abdominal ultrasound elastographic indexes and the severity of senile eterogeneous fatty liver disease.Methods One hundred patients with pathologically confirmed senile eterogeneous fatty liver disease admitted and treated in the Central Hospital of Tongchuan Mining Bureau and the Shaanxi Provincial Second People's Hospital from August 2020 to August 2022(obser-vation group)and the healthy elderly subjects in the physical examination(control group)were selected to conduct the retrospective analysis.The observation group was sub divided into the mild group,moderate group and severe group according to the severity of the condition.All subjects performed the abdominal ultrasound elastography.The elastic characteristic indexes[including strain mean(Mean),standard deviation(Sd),com-plexity(Comp),kurtosis(Kurt),skewness(Skew),contrast(Cont),evenness(Ent),clutter(Idm),consis-tency(Asm),correlation(Corr),blue area percentage(％Area)and elasticity index(Lf index)]were ob-tained by the tissue dispersion quantitative analysis software and conducted the comparison.The Spearman re-lation was adopted to analyze the correlation between the elastic characteristic indexes and the severity of se-nile heterogeneous fatty liver disease,Furthermore,the predictive value of Mean,Sd,％Area and Lf index in predicting the severity of senile heterogeneous fatty liver disease was evaluated by the receiver operating char-acteristic(ROC)curve.Results There was no statistically significant difference in Kurt and Cont between the observation group and control group(P＞0.05);the elastic characteristic indicators such as Mean,Sd,Comp,Skew,Ent,Idm,Asm,Corr,％Area and Lf index had statistical differences between the observation group and control group(P＜0.05).There was no statistically significant difference in Skew,Idm and Corr among the mild,moderate and severe groups(P＞0.05);there were statistically significant differences in Mean,Sd,Comp,Ent,Asm,％Area and Lf index among the mild,moderate and severe groups(P＜0.05).The Spearman correlation analysis results showed that Lf index,％Area,Mean and Sd had the higher correlation with the severity in senile heterogeneous fatty liver disease(r=0.633,0.492,-0.460,0.373,P＜0.05).The area under the curve(AUC)of％Area for predicting severe heterogeneous fatty liver disease was the maxi-mal,which was 0.920(95％CI:0.866-0.974).Its predictive efficiency was comparable to the Lf index(P=0.329)and superior to Mean[AUC 0.780(95％CI:0.678-0.882)]and Sd[AUC 0.752(95％CI:0.631-0.873)],and the differences were statistically significant(P=0.043,0.031).AUC of Lf index,％Area,Mean and Sd for predicting moderate to severe heterogeneous fatty liver disease were 0.801(95％CI:0.714-0.887),0.667(95％CI:0.562-0.773),0.731(95％CI:0.633-0.829)and 0.678(95％CI:0.572-0.784),respectively.The predictive efficiency of Lf index was superior to％Area,Mean and Sd(P=0.045,0.033,0.028).Conclusion Lf index,％Area,Mean and Sd in abdominal ultrasound elastographic indicators have a certain correlation with the severity of senile eterogeneous fatty liver disease.The value of Lf index and％Ar-ea in predicting the severity of senile eterogeneous fatty liver disease is optimal.关键词
非均匀性脂肪肝/老年/腹部超声/弹性成像指标Key words
heterogeneous fatty liver/senile/abdominal ultrasound/elastographic indexes分类
医药卫生
