摘要
Abstract
Objective To investigate the efficacy of trimebutene combined with Oryz-Aspergillus enzyme and pancreatin tablet in the treatment of functional dyspepsia(FD)and their effects on the intestinal flora and gastrointestinal motility.Methods Eighty-four patients with functional dyspepsia admitted and treated in this hospital from January 2021 to February 2023 were divided into the control group(42 cases)and study group(42 cases)by random number table method.The control group was treated with trimebutine,while the study group was treated with trimebutine combined with Oryz-Aspergillus enzyme and pancreatin tablet.The effica-cy and incidence rate of adverse reactions were compared between the two groups;the differences in the clini-cal symptoms,gastrointestinal motility[gastric antral contractions frequency(FB),gastric body peristalsis fre-quency(FA),gastric emptying rate(GER)],gastric receptivity(GA),intestinal microbiota count,and differ-ences in serum protease activated receptor 2 protein(PAR2),aquaporin 3(AQP3),motilin(MOT),and se-cretory curl associated protein 1(SFRP1)levels before and after treatment were compared between the two groups.Results The total effective rate in the study group was 92.86％,which was higher than 73.81％in the control group,and the difference was statistically significant(P＜0.05).There was no statistically signifi-cant difference in the scores of belching,loss of appetite,abdominal distension,abdominal pain and early satie-ty symptoms before treatment between the two groups(P＞0.05);after treatment,the scores for belching,loss of appetite,abdominal distension,abdominal pain and early satiety symptoms in the study group were lower than those in the control group(P＜0.05).There was no statistically significant difference in FA,FB,GER and GA before treatment between the two groups(P＞0.05);after treatment,the levels of FA,FB,GER and GA in the study group were higher than those in the control group(P＜0.05).There was no statistically significant difference in the number of Enterobacteriaceae,Lactobacillus,Bifidobacterium and Enterococcus be-fore treatment between the two groups(P＞0.05);after treatment,the number of Enterobacteriaceae and En-terococcus in the study group was lower than that in the control group,while the number of Lactobacillus and Bifidobacterium was higher than that in the control group,and the differences were statistically significant(P＜0.05).After treatment,the MOT level of the study group was higher than that of the control group,while the PAR2,AQP3 and SFRP1 levels were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence rate of ad-verse reactions between the study group and the control group(4.76％vs.7.14％,P＞0.05).Conclusion Trime-butene combined with Oryz-Aspergillus enzyme and pancreatin tablet has a significant effect in treating FD,it can in-crease the gastrointestinal motility and GA,and improve the intestinal microbiota and clinical symptoms.关键词
米曲菌胰酶片/功能性消化不良/曲美布汀/胃肠动力Key words
Oryz-Aspergillus enzyme and pancreatin tablet/functional dyspepsia/trimebutine/gas-trointestinal motility分类
医药卫生
